Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

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1993 • 432 citations

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The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas

1980 • 314 citations

Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells.

1979 • 283 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

[30] Tissue inhibitors of matrix metalloendopeptidases

1995 • 263 citations

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis

1996 • 255 citations

THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITIS

1995 • 234 citations

Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis

1997 • 233 citations

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1995 • 230 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium

1991 • 217 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium.

1983 • 195 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor.

1995 • 161 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

CD40 Expression by human fibroblasts

1995 • 158 citations

IFN-gamma and 1,25(OH)2D3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T cells.

1992 • 153 citations

Biologic agents for treating rheumatoid arthritis. Concepts and progress

1997 • 137 citations

Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.

1996 • 121 citations

Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: a possible role of CD69.

1993 • 118 citations

Interleukin-1, tumor necrosis factor and their specific inhibitors.

1994 • 114 citations

Mechanisms of Methotrexate Action in Rheumatoid Arthritis

1994 • 106 citations

Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop.

1995 • 102 citations

Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts

1991 • 84 citations

Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts.

1995 • 82 citations

Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate

1994 • 76 citations

Direct cell/cell contact with stimulated T lymphocytes induces the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cells

1996 • 75 citations

Monocytic cell type-specific transcriptional induction of collagenase.

1996 • 72 citations

Lymphotoxin β Receptor Triggering Induces Activation of the Nuclear Factor κB Transcription Factor in Some Cell Types

1996 • 70 citations

Recombinant human interleukin‐1 β–induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid

1992 • 66 citations

The immunopathogenesis of rheumatoid arthritis

1991 • 58 citations

Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.

1995 • 58 citations

The Prevalence and Distribution of Macrophages Bearing FcγR I, FcγR II, and FcγR III in Synovium

1990 • 52 citations

Contact-dependent stimulation of monocytic cells and neutrophils by stimulated human T-cell clones.

1995 • 48 citations

Expression and cleavage of tumor necrosis factor‐α and tumor necrosis factor receptors by human monocytic cell lines upon direct contact with stimulated T cells

1996 • 47 citations

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice

1996 • 46 citations

Early synovitis—Synoviocytes and mononuclear cells

1994 • 43 citations

An Interleukin 1 Inhibitor Affects both Cell-Associated Interleukin 1-Induced T Cell Proliferation and PGE2/Collagenase Production by Human Dermal Fibroblasts and Synovial Cells

1990 • 30 citations

Immunoregulatory T cell subsets and T cell activation in rheumatoid arthritis

1989 • 19 citations

Successful induction of severe destructive arthritis by the transfer of in vitro-activated synovial fluid T cells from patients with rheumatoid arthritis (RA) in severe combined immunodeficient (SCID) mice

1996 • 16 citations

Synovial Mononuclear Cells Consist with T Cells Which Produce High Levels of Tumor Necrosis Factor α

1997 • 6 citations