The role of nitric oxide in inflammation and immunity

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Derivation of the sledai. A disease activity index for lupus patients

1992 • 4,410 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

1997 • 1,109 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Chondrocyte apoptosis induced by nitric oxide.

1995 • 627 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases

1996 • 483 citations

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.

1996 • 438 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Nitric Oxide Activates Metalloprotease Enzymes in Articular Cartilage

1995 • 410 citations

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

1995 • 389 citations

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

1997 • 381 citations

In vivo suppression of early experimental osteoarthritis by interleukin‐1 receptor antagonist using gene therapy

1997 • 374 citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

1994 • 374 citations

Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras

1995 • 367 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Nitrosative Stress: Activation of the Transcription Factor OxyR

1996 • 351 citations

Increased nitric oxide synthesis in ulcerative colitis

1993 • 347 citations

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

1997 • 344 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Co‐induction of nitric oxide synthase and cyclo‐oxygenase: interactions between nitric oxide and prostanoids

1995 • 343 citations

Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary.

1994 • 316 citations

Modulation of adjuvant arthritis by endogenous nitric oxide

1993 • 316 citations

Nitric oxide in excitable tissues: physiological roles and disease.

1997 • 312 citations

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

1995 • 310 citations

A Novel Reaction Mechanism for the Formation of S-Nitrosothiol in Vivo

1997 • 302 citations

Nitric oxide and arthritis

1993 • 299 citations

Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients.

1996 • 285 citations

Activation of purified guanylate cyclase by nitric oxide requires heme comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

1982 • 262 citations

The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase.

1995 • 256 citations

Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium

1996 • 251 citations

Nitric Oxide: A Novel Mediator of Inflammation

1995 • 235 citations

Nitric Oxide Novel Biology with Clinical Relevance

1995 • 219 citations

Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism.

1994 • 205 citations

Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression

1997 • 202 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

Interleukin‐17 up‐regulation of nitric oxide production in human osteoarthritis cartilage

1997 • 183 citations

Up‐Regulation of Endothelial Cell Adhesion Molecules Characterizes Disease Activity in Systemic Lupus Erythematosus

1994 • 177 citations

Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes.

1995 • 167 citations

Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages.

1997 • 165 citations

Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis.

1996 • 165 citations

Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.

1996 • 153 citations

Increased nitric oxide production accompanied by the up‐regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus

1997 • 153 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

BENEFICIAL VERSUS DETRIMENTAL EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITORS IN CIRCULATORY SHOCK LESSONS LEARNED FROM EXPERIMENTAL AND CLINICAL STUDIES

1997 • 147 citations

The role of nitric oxide in multiple sclerosis

1997 • 143 citations

Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical

1996 • 140 citations

Nitric oxide regulation of superoxide-dependent lung injury: Oxidant-protective actions of endogenously produced and exogenously administered nitric oxide

1996 • 131 citations

Nitric oxide inhibits the secretion of T‐helper 1‐ and T‐helper 2‐associated cytokines in activated human T cells‘pa

1997 • 126 citations

IL-1-Induced Nitric Oxide Inhibits Chondrocyte Proliferation via PGE2

1995 • 125 citations

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

1997 • 123 citations

Interferon (IFN)-α Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti–Hepatitis C Effects of IFN-α In Vivo

1997 • 121 citations

Effects of nitric oxide on chondrocyte migration, adhesion, and cytoskeletal assembly

1996 • 120 citations

Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.

1997 • 118 citations

Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5?-diphosphate and bradykinin

1992 • 116 citations

Clinical and Serologic Manifestations of Autoimmune Disease in MRL-lpr/lpr Mice Lacking Nitric Oxide Synthase Type 2

1997 • 106 citations

[2] Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo, and in vivo studies

1996 • 101 citations

Nitric oxide production by superficial and deep articular chondrocytes

1997 • 95 citations

Role of nitric oxide in Sjögren's syndrome

1997 • 95 citations

Nitric oxide increased interleukin‐4 expression in T lymphocytes

1997 • 91 citations

Nitric oxide.

1996 • 90 citations

Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression

1994 • 89 citations

Nitric oxide stimulates ADP ribosylation of actin in association with the inhibition of actin polymerization in human neutrophils

1995 • 86 citations

Nitric oxide generation from L-arginine is required for optimal human peripheral blood lymphocyte DNA synthesis.

1991 • 84 citations

Type 1 (insulin-dependent) diabetes mellitus and nitric oxide

1992 • 84 citations

Nitric Oxide-Mediated Apoptosis in Murine Mastocytoma

1994 • 72 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury

1997 • 68 citations

Is interleukin 17, an inducible cytokine that stimulates production of other cytokines, merely a redundant player in a sea of other biomolecules?

1996 • 67 citations

Bcl‐2 prevents nitric oxide‐mediated apoptosis and poly(ADP‐ribose) polymerase cleavage

1997 • 62 citations

Effect of Late Modulation of Nitric Oxide Production on Murine Lupus

1997 • 61 citations

Modulation of human t cell responses by nitric oxide and its derivative, s‐nitrosoglutathione

1993 • 51 citations

Novel synthesis of S-nitrosoglutathione and degradation by human neutrophils

1992 • 42 citations

BENEFICIAL ACTIONS OF S-NITROSO-N-ACETYLPENICILLAMINE, A NITRIC OXIDE DONOR, IN MURINE TRAUMATIC SHOCK

1994 • 29 citations

The role of active inducible nitric oxide synthase expression in the pathogenesis of capillary leak syndrome resulting from interleukin-2 therapy in mice.

1997 • 21 citations

Biochemical Mechanisms Underlying Vascular Smooth Muscle Relaxation

1988 • 19 citations

Nitric oxide attenuates interleukin 2-induced lung injury.

1997 • 12 citations

Nitric oxide attenuates interleukin 2-induced lung injury

1997 • 8 citations