Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?

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Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

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1991 • 1,630 citations

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1992 • 667 citations

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Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

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Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

1994 • 531 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

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1992 • 473 citations

The liposome-mediated macrophage ‘suicide’ technique

1989 • 455 citations

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1992 • 452 citations

Role of interleukin‐1, tumor necrosis factor α, and interleukin‐6 in cartilage proteoglycan metabolism and destruction effect of in situ blocking in murine antigen‐ and zymosan‐induced arthritis

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1996 • 370 citations

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1992 • 363 citations

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1989 • 320 citations

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1995 • 269 citations

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1991 • 256 citations

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis

1996 • 255 citations

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1988 • 249 citations

THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITIS

1995 • 234 citations

Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.

1992 • 234 citations

DETECTION OF CYTOKINES AT THE CARTILAGE/PANNUS JUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: IMPLICATIONS FOR THE ROLE OF CYTOKINES IN CARTILAGE DESTRUCTION AND REPAIR

1992 • 233 citations

Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

1994 • 214 citations

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

1994 • 213 citations

Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells.

1994 • 209 citations

Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.

1990 • 208 citations

Identification of Three Major Synovial Lining Cell Populations by Monoclonal Antibodies Directed to Ia Antigens and Antigens Associated with Monocytes/Macrophages and Fibroblasts

1983 • 204 citations

Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability.

1993 • 202 citations

Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma.

1987 • 199 citations

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

1977 • 195 citations

Histomorphological Basis of Articular Cartilage Destruction in Rheumatoid Arthritis

1983 • 195 citations

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.

1994 • 187 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. ii. low levels of synovial fluid and synovial tissue interferon suggest that γgm‐interferon is not the primary macrophage activating factor

1987 • 177 citations

Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis.

1993 • 173 citations

Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule.

1992 • 168 citations

Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.

1992 • 164 citations

Activated T cells in vivo and in vitro: divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro.

1984 • 160 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.

1988 • 158 citations

Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients.

1973 • 132 citations

Mechanisms of Matrix Degradation in Rheumatoid Arthritis^a

1990 • 132 citations

ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats.

1991 • 129 citations

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

1995 • 125 citations

Macrophages: Current Views on Their Differentiation, Structure, and Function

1989 • 116 citations

Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. regulation of its production in synovial cells by interleukin‐1 and tumor necrosis factor

1993 • 115 citations

Interleukin-1, tumor necrosis factor and their specific inhibitors.

1994 • 114 citations

Presence of NAP‐1/IL‐8 in Synovial Fluids Indicates a Possible Pathogenic Role in Rheumatoid Arthritis

1991 • 114 citations

Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane.

1994 • 109 citations

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.

1995 • 109 citations

Comparison of the suppressive effects of interleukin-10 and interleukin-4 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis.

1995 • 103 citations

Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis

1979 • 103 citations

Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi

1992 • 103 citations

Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs

1994 • 102 citations

Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms.

1995 • 101 citations

METHOTREXATE ACTION IN RHEUMATOID ARTHRITIS: STIMULATION OF CYTOKINE INHIBITOR AND INHIBITION OF CHEMOKINE PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS

1995 • 101 citations

Presentation of self peptides by dendritic cells. Possible implications for the pathogenesis of rheumatoid arthritis

1996 • 97 citations

Immune functions of human synovial cells. phenotypic and t cell regulatory properties of macrophage‐like cells that express hla–dr

1982 • 95 citations

Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate

1992 • 94 citations

Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts.

1993 • 93 citations

Suppression of murine collagen-induced arthritis with monoclonal anti-Ia antibodies and augmentation with IFN-gamma.

1988 • 92 citations

Type II collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera.

1985 • 91 citations

Relation of cellular infiltration of rheumatoid synovial membrane to its immune response

1974 • 89 citations

Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry.

1995 • 85 citations

The role of macrophage activation in chronic inflammation

1978 • 84 citations

Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.

1993 • 82 citations

Long‐term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate‐containing liposomes

1995 • 80 citations

Antigen-presenting capacity of rheumatoid synovial fibroblasts.

1994 • 79 citations

Production of IL-1 receptor antagonist by human in vitro-derived macrophages. Effects of lipopolysaccharide and granulocyte-macrophage colony-stimulating factor.

1991 • 79 citations

Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1.

1991 • 77 citations

CRC handbook of animal models for the rheumatic diseases

1988 • 77 citations

Electron microscopic study of HLA‐DR and monocyte/macrophage staining cells in the rheumatoid synovial membrane

1986 • 75 citations

Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.

1994 • 74 citations

Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP-3) by rheumatoid synovial cells in vitro and in vivo

1993 • 73 citations

Lymphocyte depletion by continuous flow cell centrifugation in rheumatoid arthritis

1979 • 72 citations

The role of tumour necrosis factor-alpha and IL-1 in polymorphonuclear leucocyte and T lymphocyte recruitment to joint inflammation in adjuvant arthritis

1994 • 71 citations

The presence of costimulatory molecules CD86 and CD28 in rheumatoid arthritis synovium

1996 • 69 citations

Ultrastructural evidence for two distinct types of synoviocytes in rat synovial membrane

1982 • 69 citations

Studies with Radioactive Gold

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Macrophages and Dendritic Cells during the Early Stages of Antigen-Induced Arthritis in Rats: Immunohistochemical Analysis of Cryostat Sections of the Whole Knee Joint

1989 • 68 citations

Studies on the effect of methotrexate on macrophage function.

1988 • 66 citations

Regulatory effects of IL-13 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis

1995 • 65 citations

Macrophages and Dendritic Cells in Antigen‐Induced Arthritis

1987 • 64 citations

Elevated levels of TNF in the joints of adjuvant arthritic rats

1993 • 64 citations

Reduction of monocyte-macrophage activation markers upon anti-CD4 treatment. Decreased levels of IL-1, IL-6, neopterin and soluble CD14 in patients with rheumatoid arthritis

1993 • 63 citations

Differential expression of Ia antigens by rheumatoid synovial lining cells.

1987 • 62 citations

In vivo role of phagocytic synovial lining cells in onset of experimental arthritis.

1993 • 62 citations

Copper-dependent antioxidase defenses in inflammatory and autoimmune rheumatic diseases

1993 • 62 citations

Elevated expression of cd80 (b7/bb1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis

1994 • 62 citations

The metabolism and immunology of bone

1989 • 60 citations

Methotrexate inhibits macrophage activation as well as vascular and cellular inflammatory events in rat adjuvant induced arthritis.

1988 • 60 citations

Differential effects of interleukins 10 and 4 on the production of interleukin‐6 by blood and synovium monocytes in rheumatoid arthritis

1995 • 59 citations

TNF-alpha Dominates Cytokine mRNA Expression in Lymphoid Tissues of Rats Developing Collagen- and Oil-Induced Arthritis

1995 • 58 citations

Reduction of leukocyte and interleukin‐1β concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate

1993 • 57 citations

Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes

1996 • 57 citations

The gold complexes

1990 • 57 citations

Electron‐dense deposits following injection of Gold Sodium Thiomalate and Thiomalic acid

1968 • 56 citations

Monoclonal antibodies and arthritis

1990 • 56 citations

Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon γ.

1995 • 56 citations

Macrophage activation in rat models of inflammation and arthritis: Systemic activation precedes arthritis induction and progression

1986 • 54 citations

Cytokine‐induced expression of mRNAs for chemotactic factors in human synovial cells and fibroblasts

1993 • 54 citations

Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus.

1985 • 53 citations

Leucapheresis in severe rheumatoid arthritis.

1979 • 53 citations

Accelerated generation of CD14+ monocyte‐lineage cells from the bone marrow of rheumatoid arthritis patients

1996 • 53 citations

Bone resorption by cells isolated from rheumatoid synovium.

1992 • 50 citations

Distribution of macrophages in rheumatoid synovial membrane and its association with basic activity

1994 • 49 citations

Expression of e‐selectin messenger RNA and protein in rheumatoid arthritis

1995 • 48 citations

The Origin of Type A Synovial Lining Cells

1982 • 48 citations

Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF

1993 • 48 citations

Arthritis induced by continuous infusion of hr-interleukin-1 alpha into the rabbit knee-joint.

1989 • 46 citations

Inhibitors of reactive oxygen intermediates suppress bacterial cell wall-induced arthritis.

1991 • 45 citations

The far upstream chicken lysozyme enhancer at -6.1 kilobase, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells.

1994 • 43 citations

The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes.

1982 • 41 citations

Profile of Cytokines in Synovial Fluid Specimens from Patients with Arthritis. Interleukin 8 (IL-8) and IL-6 Correlate with Inflammatory Arthritides

1992 • 41 citations

Distribution of gold in the animal body in relation to arthritis.

1948 • 41 citations

Antigenicity and accessory cell function of human articular chondrocytes.

1991 • 39 citations

Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate.

1971 • 39 citations

Results of a phase-II clinical trial on treatment of rheumatoid arthritis with recombinant interferon-gamma

1987 • 38 citations

Monocyte activation in early onset rheumatoid arthritis.

1990 • 38 citations

Reactivity of an active center analog of Cu2Zn2superoxide dismutase in murine model of acute and chronic inflammation

1993 • 38 citations

In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine.

1991 • 38 citations

Cytokines and oncogenes in cellular interactions of rheumatoid arthritis

1994 • 37 citations

Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metalloproteinase-mediated connective tissue degradation.

1993 • 36 citations

Expression of ICAM‐R (ICAM‐3), a novel counter‐receptor for LFA‐1, in rheumatoid and nonrheumatoid synovium

1994 • 35 citations

The effect of free and liposome-encapsulated clodronate on the hepatic mononuclear phagocyte system in the rat

1995 • 35 citations

Immunohistological analysis of the synovial membrane: search for predictors of the clinical course in rheumatoid arthritis.

1991 • 33 citations

Treatment of Rat Arthritides with Clodronate-Containing Liposomes

1995 • 32 citations

The anatomy of the rheumatoid lesion

1995 • 30 citations

Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity

1991 • 29 citations

Monocyte dependent excited oxygen radical generation in rheumatoid arthritis: inhibition by gold sodium thiomalate.

1983 • 29 citations

The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytesin vitro:variation in healthy subjects and patients with arthritis

1990 • 28 citations

Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis.

1984 • 27 citations

Production of interleukin 1 in the joint during the development of antigen-induced arthritis in the rabbit.

1988 • 27 citations

Macrophage activation in rat models of inflammation and arthritis: Determination of markers of stages of activation

1986 • 26 citations

Effect of Treatment with Interferon-γ and Concanavalin A on the Course of Infection of Mice withSalmonella typhimuriumStrain LT-2

1987 • 26 citations

Coiling Phagocytosis: A Way for MHC Class I Presentation of Bacterial Antigens?

1994 • 25 citations

Phagocytic synovial lining cells in experimentally induced chronic arthritis: down-regulation of synovitis by CL2MDP-liposomes

1994 • 25 citations

Borrelia burgdorferi‐induced ultrastructural alterations in human phacgocytes: A clue to pathogenicity?

1994 • 25 citations

Comparative studies of collagenase and stromelysin-1 expression by rheumatoid synoviocytes in vitro

1995 • 24 citations

Interleukin 1 mediated acceleration of type II collagen-induced arthritis: Effects of anti-inflammatory or anti-arthritic drugs

1991 • 24 citations

Prostaglandin and tumor necrosis factor secretion by peritoneal macrophages isolated from normal and arthritic rats treated with liposomal methotrexate

1994 • 21 citations

Adjuvant‐induced polyarthritis. synovial cell activation prior to polyarthritis onset

1988 • 21 citations

Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis.

1984 • 20 citations

Immunohistochemical changes in synovial tissue during the course of adjuvant arthritis.

1995 • 19 citations

Establishment and Characterization of Synovial Cell Clones with Integrated Human T-Cell Leukemia Virus Type-I

1994 • 18 citations

Differential effects of IL-1 and TNF alpha on the expression of stromelysin, collagenase and their natural inhibitor, TIMP, in rheumatoid human synovial fibroblasts.

1992 • 17 citations

Expression of the ED3 Antigen on Rat Macrophages in Relation to Experimental Autoimmune Diseases

1992 • 16 citations

Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease: Phenotypic and Functional Analysis

1991 • 16 citations

Activation and differentiation of myelomonocytic cells in rheumatoid arthritis and healthy individuals--evidence for antagonistic in vitro regulation by interferon-gamma and tumor necrosis factor alpha, granulocyte monocyte colony stimulating factor and interleukin 1.

1992 • 15 citations

Suppressed IL-2 production and response in AA rats: role of suppressor cells and the effect of auranofin treatment.

1985 • 12 citations

Lymphapheresis in rheumatoid arthritis. The clinical and laboratory effects of a limited course of cell depletion.

1983 • 11 citations

Monocyte fc receptor function in rheumatoid arthritis. enhanced cell‐binding of igg induced by rheumatoid factors

1987 • 11 citations

Lymphocyte-macrophage co-operation during induction of T-suppressor cell activity in rats with adjuvant arthritis.

1983 • 11 citations

Is Recombinant Interleukin-2 the Best Way to Deliver Interferon-γ in Human Disease?

1987 • 7 citations

Human monocyte elastolytic activity, the propeptides of types I and III procollagen, proteoglycans, and interleukin-6 in synovial fluid from patients with arthritis.

1991 • 6 citations

Induction of a lymphotoxin-like mediator in peripheral blood and synovial fluid lymphocytes by incubation with synovial fluid from patients with rheumatoid arthritis

1981 • 5 citations

The role of MHC class II antigens in the flare up reaction of antigen-induced arthritis in mice

1986 • 2 citations

Deleted Work

1955 • 0 citations