Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1999 • 1,660 citations

HISTOCHEMICAL METHODS FOR ACID PHOSPHATASE USING HEXAZONIUM PARAROSANILIN AS COUPLER

1962 • 1,599 citations

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

2000 • 588 citations

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

1998 • 451 citations

Alcian Blue 8GS: A New Stain for Mucin

1950 • 418 citations

IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells

1999 • 415 citations

The role of nitric oxide in inflammation and immunity

1998 • 413 citations

Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB

1998 • 386 citations

In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes.

1982 • 333 citations

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

2001 • 328 citations

The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives

1997 • 295 citations

CONTRIBUTION OF INTERLEUKIN 17 TO SYNOVIUM MATRIX DESTRUCTION IN RHEUMATOID ARTHRITIS

2000 • 278 citations

Pathogenesis of joint damage in rheumatoid arthritis.

1999 • 222 citations

Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones

1995 • 218 citations

The combination of tumor necrosis factor ? blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model

2001 • 198 citations

Peroxisome proliferator-activated receptor ? activators inhibit interleukin-1?-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes

2001 • 198 citations

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption.

1994 • 198 citations

Interleukin‐17 up‐regulation of nitric oxide production in human osteoarthritis cartilage

1997 • 183 citations

THE ROLE OF NITRIC OXIDE IN ARTICULAR CARTILAGE DAMAGE

1999 • 170 citations

Interleukin-17: A New Bone Acting Cytokine In Vitro

1999 • 167 citations

Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases

1998 • 158 citations

Stimulation of 92‐kd gelatinase (matrix metalloproteinase 9) production by interleukin‐17 in human monocyte/macrophages: A possible role in rheumatoid arthritis

2000 • 157 citations

Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: A possible role in rheumatoid arthritis

2000 • 145 citations

Marimastat (BB2516): Current status of development

1999 • 131 citations

Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures

1997 • 122 citations

Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction

1999 • 110 citations

PATHWAYS BY WHICH INTERLEUKIN 17 INDUCES ARTICULAR CARTILAGE BREAKDOWN IN VITRO AND IN VIVO

2001 • 109 citations

The matrix metalloproteinases and their inhibitors in pancreatic cancer

1997 • 108 citations

High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients

2001 • 101 citations

Reduction of interleukin‐17–induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin‐4

2000 • 100 citations

Matrix metalloproteinase inhibitors in rheumatic diseases

2001 • 95 citations

The Prevention of Collagen Breakdown in Bovine Nasal Cartilage by TIMP, TIMP-2 and a Low Molecular Weight Synthetic Inhibitor

1994 • 89 citations

Interleukin-17 and its receptor.

1997 • 83 citations

Effect of interleukin 17 on proteoglycan degradation in murine knee joints

2000 • 74 citations

Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts

2000 • 67 citations

Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-κB and receptor activator of nuclear factor κB (RANK)/RANK ligand signaling?

2001 • 62 citations

Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.

1991 • 51 citations

Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.

2001 • 48 citations

Are T cells in rheumatoid synovium aggressors or bystanders?

2000 • 40 citations

POTENTIAL CONTRIBUTION OF IL-17- PRODUCING TH1CELLS TO DEFECTIVE REPAIR ACTIVITY IN JOINT INFLAMMATION: PARTIAL CORRECTION WITH Th2-PROMOTING CONDITIONS

2001 • 37 citations

T cells: Pathogenic cells and therapeutic targets in rheumatoid arthritis

1999 • 35 citations

Nitric Oxide in the Local Host Reaction to Total Hip Replacement

1998 • 35 citations

Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis and other rheumatic diseases (April 2001)

2001 • 32 citations

New insights in the pathogenesis of rheumatoid arthritis.

1998 • 30 citations

The levels of memory (CD45RA?, RO+) CD4+ and CD8+ peripheral blood T-lymphocytes correlate with IgM rheumatoid factors in rheumatoid arthritis

1996 • 29 citations

Interleukin 13 and its Receptor

1998 • 20 citations

T cells and related cytokines

1998 • 13 citations

Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown

1998 • 13 citations