Control of Cardiac Development by an Evolutionarily Conserved Transcriptional Network

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2000 • 5,882 citations

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1978 • 3,910 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

1998 • 1,026 citations

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

1997 • 1,024 citations

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

2001 • 1,022 citations

Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

2001 • 883 citations

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

1993 • 790 citations

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

1993 • 719 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

A role for bone morphogenetic proteins in the induction of cardiac myogenesis.

1997 • 687 citations

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

1997 • 660 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

A genetic blueprint for cardiac development

2000 • 633 citations

Postembryonic Hematopoiesis in Drosophila

2001 • 609 citations

Inhibition of Wnt activity induces heart formation from posterior mesoderm

2001 • 581 citations

GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.

1994 • 567 citations

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1950 • 565 citations

twist and snail as positive and negative regulators during Drosophila mesoderm development.

1991 • 550 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

1993 • 533 citations

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

1999 • 502 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Wnt antagonism initiates cardiogenesis in Xenopus laevis

2001 • 479 citations

Induction of avian cardiac myogenesis by anterior endoderm

1995 • 475 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Drosophila MEF2, a transcription factor that is essential for myogenesis.

1995 • 426 citations

Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

1995 • 419 citations

FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium

2000 • 409 citations

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

1999 • 367 citations

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

1991 • 361 citations

The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development

2000 • 330 citations

Genomic Regulatory Systems

2001 • 327 citations

Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors

2000 • 324 citations

TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads

1999 • 324 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

1996 • 303 citations

GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression

1998 • 303 citations

Requirement of the MADS-box transcription factor MEF2C for vascular development

1998 • 302 citations

heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.

1996 • 298 citations

Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5

1995 • 289 citations

Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes

1999 • 279 citations

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

1998 • 274 citations

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

1999 • 266 citations

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)

2000 • 262 citations

Wnt signals from the neural tube block ectopic cardiogenesis

2001 • 250 citations

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm

1998 • 250 citations

Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4

1999 • 245 citations

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product

1991 • 236 citations

The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

1992 • 233 citations

FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors

1999 • 222 citations

Heart Development in Drosophila Requires the Segment Polarity Gene wingless

1995 • 221 citations

FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped

1999 • 209 citations

A Series of Mutations in the D-MEF2 Transcription Factor Reveal Multiple Functions in Larval and Adult Myogenesis in Drosophila

1995 • 209 citations

TheXenopusGATA-4/5/6 Genes Are Associated with Cardiac Specification and Can Regulate Cardiac-Specific Transcription during Embryogenesis

1996 • 202 citations

BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos

1998 • 197 citations

The Wingless Signaling Pathway Is Directly Involved inDrosophilaHeart Development

1996 • 193 citations

Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm

1998 • 193 citations

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

2001 • 188 citations

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice

1998 • 188 citations

The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins

1991 • 187 citations

Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development

1997 • 186 citations

The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system

1996 • 185 citations

Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription

1999 • 184 citations

A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2

2000 • 177 citations

Embryonic origin and differentiation of the Drosophila heart

1994 • 177 citations

Heart development in Drosophila and its relationship to vertebrates

1995 • 173 citations

Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS

1997 • 173 citations

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice

1998 • 171 citations

A genomewide survey of basic helix–loop–helix factors in Drosophila

2000 • 169 citations

The Drosophila Protein Dof Is Specifically Required for FGF Signaling

1998 • 166 citations

Parsing the Heart: Genetic Modules for Organ Assembly

1997 • 163 citations

Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells

2001 • 158 citations

BMP Signaling Is Required for Heart Formation in Vertebrates

2000 • 157 citations

The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila

1999 • 156 citations

The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis

1998 • 154 citations

The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium

1996 • 152 citations

Characterization of a novel subset of cardiac cells and their progenitors in theDrosophilaembryo

2000 • 151 citations

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart

2000 • 151 citations

D-mef2 is a target for Tinman activation during Drosophila heart development

1997 • 148 citations

Control of cell fates and segmentation in the Drosophila mesoderm

1997 • 148 citations

inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis

1998 • 145 citations

Segmental patterning of heart precursors in Drosophila

1995 • 140 citations

Laminin Is Required for Heart, Somatic Muscles, and Gut Development in the Drosophila Embryo

1995 • 138 citations

Cardiac-Specific Activity of an Nkx2–5 Enhancer Requires an Evolutionarily Conserved Smad Binding Site

2002 • 133 citations

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.

1991 • 132 citations

ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors

1997 • 125 citations

Direct Activation of a GATA6 Cardiac Enhancer by Nkx2.5: Evidence for a Reinforcing Regulatory Network of Nkx2.5 and GATA Transcription Factors in the Developing Heart

2000 • 116 citations

Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature

1995 • 113 citations

Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5

1999 • 112 citations

Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo

1998 • 109 citations

zfh-1, the Drosophila Homologue of ZEB, Is a Transcriptional Repressor That Regulates Somatic Myogenesis

1999 • 103 citations

Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired

2000 • 98 citations

Regulation and function oftinman during dorsal mesoderm induction and heart specification inDrosophila

1998 • 95 citations

Nkx-2.5 Gene Induction in Mice Is Mediated by a Smad Consensus Regulatory Region

2002 • 93 citations

Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5

1999 • 87 citations

Genetically distinct cardial cells within theDrosophila heart

2000 • 86 citations

The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision

1999 • 86 citations

Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation.

1994 • 82 citations

Identification of Immune System and Response Genes, and Novel Mutations Causing Melanotic Tumor Formation in Drosophila melanogaster

1996 • 82 citations

Genetic Determination of Drosophila Heart Development

1999 • 80 citations

A Conserved Role for H15-Related T-Box Transcription Factors in Zebrafish and Drosophila Heart Formation

2000 • 80 citations

Irx4 Forms an Inhibitory Complex with the Vitamin D and Retinoic X Receptors to Regulate Cardiac Chamber-specific slow MyHC3Expression

2001 • 75 citations

Drosophila mef2Expression during Mesoderm Development Is Controlled by a Complex Array ofcis-Acting Regulatory Modules

1998 • 75 citations

Pannier is a Transcriptional Target and Partner of Tinman during Drosophila Cardiogenesis

2001 • 74 citations

Myocyte-specific enhancer factor 2 acts cooperatively with a muscle activator region to regulate Drosophila tropomyosin gene muscle expression.

1996 • 72 citations

A Novel Sulfonylurea Receptor Family Member Expressed in the Embryonic Drosophila Dorsal Vessel and Tracheal System

1999 • 72 citations

The Role of Cell Adhesion Molecules inDrosophilaHeart Morphogenesis:Faint Sausage, Shotgun/DE-Cadherin, andLaminin AAre Required for Discrete Stages in Heart Development

1999 • 70 citations

The Heterotrimeric Protein Go Is Required for the Formation of Heart Epithelium in Drosophila

1999 • 69 citations

Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory Elements

1997 • 66 citations

Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages

2002 • 66 citations

Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates inDrosophila

2002 • 60 citations

The Homeodomain Transcription Factor NK-4 Acts as either a Transcriptional Activator or Repressor and Interacts with the p300 Coactivator and the Groucho Corepressor

1999 • 59 citations

Intersecting signalling and transcriptional pathways inDrosophilaheart specification

1999 • 53 citations

The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo

2000 • 53 citations

Heart development: learning from mistakes

2002 • 52 citations

Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman -related genes

1998 • 49 citations

Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages

1998 • 47 citations

Patterning during organogenesis: genetic analysis of cardiac chamber formation

1999 • 45 citations

Transcription of the Myogenic Regulatory Gene Mef2 in Cardiac, Somatic, and Visceral Muscle Cell Lineages Is Regulated by a Tinman-Dependent Core Enhancer

1999 • 44 citations

odd-skipped is expressed in multiple tissues during Drosophila embryogenesis

2000 • 43 citations

Cardiac enhancer activity of the homeobox genetinman depends on CREB consensus binding sites inDrosophila

2000 • 42 citations

Tinman Regulates the Transcription of the β3 tubulin Gene (βTub60D) in the Dorsal Vessel of Drosophila

1999 • 40 citations

Conserved Cardiogenic Functions of the Multitype Zinc-Finger Proteins

2001 • 37 citations

The Chicken GATA-6 Locus Contains Multiple Control Regions That Confer Distinct Patterns of Heart Region-specific Expression in Transgenic Mouse Embryos

1997 • 34 citations

Dual role for thezeste-white3/shaggy-encoded kinase in mesoderm and heart development ofDrosophila

1998 • 27 citations

The pioneer gene, apontic, is required for morphogenesis and function of the Drosophila heart

1999 • 20 citations

Le projet de la Vie de Henry Brulard

2001 • 1 citations