Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

The Role of Extracellular Matrix in Development

1985 • 867 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

A role for bone morphogenetic proteins in the induction of cardiac myogenesis.

1997 • 687 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Fashioning the vertebrate heart: earliest embryonic decisions

1997 • 490 citations

Evidence from normal expression and targeted misexpression that Bone Morphogenetic Protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis

1996 • 480 citations

Structural development of endocardial cushions

1977 • 468 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects inBMP7 deficient embryos

1997 • 448 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1995 • 424 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Localization and actions of transforming growth factor-βs in the embryonic nervous system

1991 • 360 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

1995 • 326 citations

In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2

1990 • 325 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Cardiac Neural Crest Cells Provide New Insight into Septation of the Cardiac Outflow Tract: Aortic Sac to Ventricular Septal Closure

1998 • 287 citations

Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β

1989 • 286 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

1992 • 268 citations

Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissue

1983 • 265 citations

Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation.

1987 • 264 citations

Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.

1991 • 263 citations

Structural analysis of endocardial cytodifferentiation

1975 • 255 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis

1990 • 239 citations

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

1990 • 226 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors

1993 • 215 citations

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin.

1992 • 204 citations

Expression of transforming growth factor β2 RNA during murine embryogenesis

1989 • 202 citations

TGFβ2 and TGFβ3 Have Separate and Sequential Activities during Epithelial–Mesenchymal Cell Transformation in the Embryonic Heart

1999 • 201 citations

Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.

1994 • 192 citations

Bovine Latent Transforming Growth Factor β1-Binding Protein 2: Molecular Cloning, Identification of Tissue Isoforms, and Immunolocalization to Elastin-Associated Microfibrils

1995 • 186 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture system

1982 • 179 citations

Expression of homeobox genes Msx‐1 (Hox‐7) and Msx‐2 (Hox‐8) during cardiac development in the chick

1993 • 169 citations

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development

1993 • 166 citations

Cardiac Morphogenesis—Recent Research Advances

1987 • 164 citations

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

1990 • 162 citations

Myocardial specificity for initiating endothelial-mesenchymal cell transition in embryonic chick heart correlates with a particulate distribution of fibronectin

1987 • 158 citations

Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick

1995 • 151 citations

Mesoderm Induction by BMP-4 and -7 Heterodimers

1997 • 147 citations

Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3)

1995 • 147 citations

Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex

1989 • 144 citations

Expression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue: A role for transforming growth factor β3

1997 • 141 citations

Protein extracts from early embryonic hearts initiate cardiac endothelial cytodifferentiation

1985 • 136 citations

Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos

1988 • 136 citations

N-Cadherin–Catenin Interaction: Necessary Component of Cardiac Cell Compartmentalization during Early Vertebrate Heart Development

1997 • 135 citations

Independent Changes in Type I and Type II Receptors for Transforming Growth Factor β Induced by Bone Morphogenetic Protein 2 Parallel Expression of the Osteoblast Phenotype

1995 • 132 citations

Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiation

1987 • 129 citations

Antibodies to the Type II TGFβ Receptor Block Cell Activation and Migration during Atrioventricular Cushion Transformation in the Heart

1996 • 126 citations

Cardiac Endothelial Heterogeneity Defines Valvular Development as Demonstrated by the Diverse Expression of JB3, an Antigen of the Endocardial Cushion Tissue

1994 • 125 citations

Extracellular Fibrillar Structure of Latent TGFβ Binding Protein-1: Role in TGFβ-dependent Endothelial-Mesenchymal Transformation during Endocardial Cushion Tissue Formation in Mouse Embryonic Heart

1997 • 123 citations

The primitive cardiac regions in the straight tube heart (Stage 9) and their anatomical expression in the mature heart: An experimental study in the chick embryo.

1989 • 123 citations

Distribution of basement membrane antigens in cryopreserved early embryonic hearts

1987 • 121 citations

Efficient Expression of a Heterodimer of Bone Morphogenetic Protein Subunits Using a Baculovirus Expression System

1995 • 119 citations

Expression of TGF-βs and Their Receptors during Implantation and Organogenesis of the Mouse Embryo

1994 • 119 citations

Induction of Endocardial Cushion Tissue in the Avian Heart is Regulated, in Part, by TGFβ-3-Mediated Autocrine Signaling

1997 • 95 citations

Early heart development: Dynamics of endocardial cell sorting suggests a common origin with cardiomyocytes

1993 • 92 citations

Conditioning of native substrates by chondroitin sulfate proteoglycans during cardiac mesenchymal cell migration.

1986 • 79 citations

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

1992 • 78 citations

Expression of transforming growth factor-β2 and β3 mRNAs and proteins in the developing chicken embryo

1994 • 77 citations

Bone morphogenetic protein-2 acts synergistically with transforming growth factor-?3 during endothelial-mesenchymal transformation in the developing chick heart

1999 • 76 citations

Morphological Observations on the Pathogenetic Process of Transposition of the Great Arteries Induced by Retinoic Acid in Mice

1995 • 73 citations

Myocardial Regulation of Transforming Growth Factor-β Expression by Outflow Tract Endothelium in the Early Embryonic Chick Heart

1994 • 72 citations

Evolutionary Origins of the Transforming Growth Factor-β Gene Family

1992 • 71 citations

Expression of adhesion molecules during the formation and differentiation of the avian endocardial cushion tissue

1991 • 67 citations

Identification of an extracellular 130-kDa protein involved in early cardiac morphogenesis

1993 • 65 citations

Identification of the developmental marker, JB3-antigen, as fibrillin-2 and its de novo organization into embryonic microfibrous arrays

1998 • 63 citations

Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGF? signal transduction mechanisms

1999 • 60 citations

Fibulin-1, vitronectin, and fibronectin expression during avian cardiac valve and septa development

1996 • 60 citations

An ultrastructual topographical study on myofibrillogenesis in the heart of the chick embryo during pulsation onset period

1985 • 59 citations

A comparison of fibronectin, laminin, and galactosyltransferase adhesion mechanisms during embryonic cardiac mesenchymal cell migration in vitro

1990 • 58 citations

Influence of the endoderm on heart differentiation during the early stages of development of the chicken embryo

1963 • 58 citations

An Autocrine Function for Transforming Growth Factor (TGF)-β3 in the Transformation of Atrioventricular Canal Endocardium into Mesenchyme during Chick Heart Development

1998 • 57 citations

Distribution of laminin, collagen type IV, collagen type I, and fibronectin in chicken cardiac jelly/basement membrane

1989 • 53 citations

An antiserum (ES1) against a particulate form of extracellular matrix blocks the transition of cardiac endothelium into mesenchyme in culture

1991 • 53 citations

DEVELOPMENT OF PACEMAKER TISSUE IN THE EMBRYONIC HEART

1965 • 49 citations

An indirect immunofluorescence study of the distribution of fibronectin during the formation of the cushion tissue mesenchyme in the embryonic heart

1984 • 49 citations

Initial expression of type I procollagen in chick cardiac mesenchyme is dependent upon myocardial stimulation

1988 • 48 citations

Fibronectin distribution during early chick embryo heart development

1983 • 43 citations

Urokinase activity in the developing avian heart: A spatial and temporal analysis

1992 • 42 citations

Indirect immunofluorescent staining of fibronectin associated with the floor of the foregut during formation and rupture of the oral membrane in the chick embryo

1980 • 41 citations

Thrombospondins selectively activate one of the two latent forms of transforming growth factor-beta present in adrenocortical cell-conditioned medium.

1995 • 40 citations

Inhibition of outflow cushion mesenchyme formation in retinoic acid-induced complete transposition of the great arteries

1996 • 34 citations

Expression of collagenase and IL‐1α in developing rat hearts

1992 • 34 citations

Anomalous looping, atrioventricular cushion dysplasia, and unilateral ventricular hypoplasia in the mouse embryos with right isomerism induced by retinoic acid

1998 • 32 citations

Identification of transferrin as one of multiple EDTA‐extractable extracellular proteins involved in early chick heart morphogenesis

1994 • 30 citations

Expression of TGFβ3 RNA during chick embryogenesis: a possible important role in cardiovascular development

1999 • 29 citations

Specific configurations of fibronectin‐containing particles correlate with pathways taken by neural crest cells at two axial levels

1988 • 29 citations

Growth factors and signal transduction in development

1995 • 29 citations

Hypoplasia of cushion ridges in the proximal outflow tract elicits formation of a right ventricle-to-aortic route in retinoic acid-induced complete transposition of the great arteries in the mouse: Scanning electron microscopic observations of corrosion cast models

1996 • 26 citations

Immunolocalization of latent transforming growth factor-� binding protein-1 (LTBP1) during mouse development: possible roles in epithelial and mesenchymal cytodifferentiation

1999 • 24 citations

Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries

1997 • 24 citations

Transforming growth factor-?1 localized within the heart of the chick embryo

1991 • 19 citations

A Subset of SBA Lectin-Binding Proteins Isolated from Myocardial-Conditioned Media Transforms Cardiac Endothelium into Mesenchyme

1995 • 18 citations

Partial purification of HLAMP-1 provides direct evidence for the multicomponent nature of the particulate matrix associated with cardiac mesenchyme formation

1997 • 17 citations

Expression of TGFβ1/β3 during early chick embryo development

1994 • 16 citations

Estradiol-induced changes in rabbit luteal cell progestin production and cholesterol and cholesterol ester content

1983 • 14 citations

All‐Trans Retinoic Acid Induced Cardiovascular Malformations

1990 • 14 citations

Identification of a 283-kDa Protein Component of the Particulate Matrix Associated with Cardiac Mesenchyme Formation

1996 • 14 citations

Optical Indications of Spontaneous Electrical Activity and Functional Organization of Pacemaking Area in the Early Embryonic Chick Heart

1990 • 3 citations