Cardiomyocyte Cell Cycle Regulation

Bone marrow cells regenerate infarcted myocardium

2001 • 5,234 citations

Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart

2002 • 2,242 citations

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

2002 • 2,028 citations

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

2001 • 1,999 citations

Changing potency by spontaneous fusion

2002 • 1,525 citations

HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

1998 • 1,471 citations

Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction

2001 • 1,437 citations

Chimerism of the Transplanted Heart

2002 • 1,295 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.

1996 • 1,152 citations

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

1997 • 1,138 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.

1997 • 1,031 citations

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

1997 • 1,024 citations

Rapid Transition of Cardiac Myocytes from Hyperplasia to Hypertrophy During Postnatal Development

1996 • 800 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

Cardiomyocyte DNA synthesis and binucleation during murine development

1996 • 699 citations

A genetic blueprint for cardiac development

2000 • 633 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Inhibition of Wnt activity induces heart formation from posterior mesoderm

2001 • 581 citations

Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis

1998 • 555 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Molecular Pathways Controlling Heart Development

1996 • 485 citations

Chamber Formation and Morphogenesis in the Developing Mammalian Heart

2000 • 483 citations

Wnt antagonism initiates cardiogenesis in Xenopus laevis

2001 • 479 citations

Evidence for Cardiomyocyte Repopulation by Extracardiac Progenitors in Transplanted Human Hearts

2002 • 439 citations

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1998 • 422 citations

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

1998 • 395 citations

Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration

2001 • 366 citations

Primitive-Streak Origin of the Cardiovascular System in Avian Embryos

1993 • 362 citations

Serotonin 2B receptor is required for heart development

2000 • 357 citations

Inactivation of erythropoietin leads to defects in cardiac morphogenesis

1999 • 343 citations

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

1992 • 314 citations

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

1996 • 293 citations

Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts

1997 • 292 citations

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

2001 • 285 citations

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1998 • 285 citations

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.

1999 • 277 citations

HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

1999 • 276 citations

Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias in Mice

1988 • 275 citations

Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy.

1984 • 260 citations

Wnt signals from the neural tube block ectopic cardiogenesis

2001 • 250 citations

Expression of the Novel Basic Helix-Loop-Helix Gene eHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

1995 • 248 citations

Heart regeneration in adult MRL mice

2001 • 247 citations

Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4

1999 • 245 citations

Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.

1997 • 243 citations

An inductive role for the endoderm in Xenopus cardiogenesis

1995 • 234 citations

Mesoderm movement and fate during avian gastrulation and neurulation

1992 • 232 citations

Bmp6 and Bmp7 Are Required for Cushion Formation and Septation in the Developing Mouse Heart

2001 • 217 citations

Overexpression of angiotensin AT ₁ receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

1997 • 214 citations

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.

1997 • 207 citations

Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture.

1995 • 193 citations

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

1993 • 193 citations

Cell Transplantation as Future Therapy for Cardiovascular Disease?

2000 • 189 citations

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

1995 • 186 citations

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survivals

1996 • 183 citations

1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy

1997 • 183 citations

The c-myc proto-oncogene regulates cardiac development in transgenic mice.

1990 • 181 citations

Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene

1998 • 181 citations

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication‐defective retrovirus: I. Formation of the ventricular myocardium

1992 • 180 citations

A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2

2000 • 177 citations

Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.

1993 • 155 citations

Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen.

1988 • 155 citations

Adenovirus E1A Represses Cardiac Gene Transcription and Reactivates DNA Synthesis in Ventricular Myocytes, via Alternative Pocket Protein- and p300-binding Domains

1995 • 153 citations

Adult-Derived Stem Cells from the Liver Become Myocytes in the Heart in Vivo

2001 • 139 citations

Inducible Activation of c-Myc in Adult Myocardium In Vivo Provokes Cardiac Myocyte Hypertrophy and Reactivation of DNA Synthesis

2001 • 138 citations

The retinoblastoma gene family is differentially expressed during embryogenesis

1997 • 138 citations

Fluorescence in situ hybridization for the Y-chromosome can be used to detect cells of recipient origin in allografted hearts following cardiac transplantation.

1993 • 133 citations

TBX5 Transcription Factor Regulates Cell Proliferation during Cardiogenesis

2001 • 124 citations

Human E2F-1 Reactivates Cell Cycle Progression in Ventricular Myocytes and Represses Cardiac Gene Transcription

1996 • 120 citations

High and Low Molecular Weight Fibroblast Growth Factor-2 Increase Proliferation of Neonatal Rat Cardiac Myocytes but Have Differential Effects on Binucleation and Nuclear Morphology

1996 • 116 citations

jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background

1999 • 108 citations

Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.

1995 • 103 citations

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication‐defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes

1992 • 102 citations

Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice

1990 • 101 citations

Stimulation and inhibition of cardiac myocyte proliferation in vitro

1990 • 100 citations

Heart and bone tumors in transgenic mice.

1988 • 98 citations

Altered Expression of Cell Cycle Proteins and Prolonged Duration of Cardiac Myocyte Hyperplasia in p27 ^KIP1 Knockout Mice

1999 • 96 citations

Cardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes

1992 • 95 citations

Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein.

1996 • 93 citations

Cardiac-Specific Overexpression of Cyclin-Dependent Kinase 2 Increases Smaller Mononuclear Cardiomyocytes

2001 • 92 citations

The development and regenerative potential of cardiac muscle

1991 • 89 citations

Inhibition of Precardiac Mesoderm Cell Proliferation by Antisense Oligodeoxynucleotide Complementary to Fibroblast Growth Factor-2 (FGF-2)

1993 • 89 citations

Cell cycle profiles and expressions of p21CIP1 and p27KIP1 during myocyte development

1998 • 80 citations

E2F-1 Overexpression in Cardiomyocytes Induces Downregulation of p21 ^CIP1 and p27 ^KIP1 and Release of Active Cyclin-Dependent Kinases in the Presence of Insulin-Like Growth Factor I

1999 • 79 citations

Tumor suppressor gene expression during normal and pathologic myocardial growth.

1994 • 76 citations

Changes in E2F Complexes Containing Retinoblastoma Protein Family Members and Increased Cyclin-dependent Kinase Inhibitor Activities During Terminal Differentiation of Cardiomyocytes

1998 • 76 citations

An Intrinsic Timer That Controls Cell-Cycle Withdrawal in Cultured Cardiac Myocytes

1999 • 75 citations

Inducible Gene Targeting in Postnatal Myocardium by Cardiac-Specific Expression of a Hormone-Activated Cre Fusion Protein

2001 • 73 citations

Simian Virus 40 Large T Antigen Binds a Novel Bcl-2 Homology Domain 3-containing Proapoptosis Protein in the Cytoplasm

2000 • 71 citations

Growth factors and TPA stimulate DNA synthesis and alter the morphology of cultured terminally differentiated adult rat cardiac muscle cells

1988 • 69 citations

Mitogenic effect of erythropoietin on neonatal rat cardiomyocytes: Signal transduction pathways

1996 • 69 citations

Morphogenesis of the truncus arteriosus of the chick embryo heart: The formation and migration of mesenchymal tissue

1979 • 66 citations

Proliferating cell nuclear antigen in developing and adult rat cardiac muscle cells.

1991 • 63 citations

Enhanced Cardiomyocyte DNA Synthesis During Myocardial Hypertrophy in Mice Expressing a Modified TSC2 Transgene

2000 • 60 citations

Differential and Dramatic Changes of Cyclin-dependent Kinase Activities in Cardiomyocytes During the Neonatal Period

1997 • 57 citations

Trk C Receptor Signaling Regulates Cardiac Myocyte Proliferation during Early Heart Development in Vivo

2000 • 56 citations

Insulin-like Growth Factor-1 Receptor and Its Ligand Regulate the Reentry of Adult Ventricular Myocytes into the Cell Cycle

1997 • 55 citations

Regulation of proliferation of the fetal myocardium

2000 • 52 citations

Cyclins and Cyclin Dependent Kinases during Cardiac Development

1997 • 49 citations

Over-expression of CUG- or AUG-initiated Forms of Basic Fibroblast Growth Factor in Cardiac Myocytes Results in Similar Effects on Mitosis and Protein Synthesis but Distinct Nuclear Morphologies

1994 • 48 citations

Cell proliferation in the growing human heart: MIB-1 immunostaining in preterm and term infants at autopsy

2001 • 48 citations

Persistent and Heterogenous Expression of the Cyclin-dependent Kinase Inhibitor, p27KIP1, in Rat Hearts During Development

1998 • 47 citations

Transforming growth factor-beta1 in heart development

1992 • 44 citations

Autoradiographic study on the synthesis of DNA, RNA, and proteins in normal cardiac muscle cells and those changed by experimental injury.

1966 • 42 citations

Atrial natriuretic peptide accelerates proliferation of chick embryonic cardiomyocytes in vitro

1996 • 40 citations

A Constitutive Mutation ofALK5Disrupts Cardiac Looping and Morphogenesis in Mice

1998 • 39 citations

E1A Can Provoke G1 Exit That Is Refractory to p21 and Independent of Activating Cdk2

1999 • 38 citations

Coexpression of Mutant p53 and p193 Renders Embryonic Stem Cell–Derived Cardiomyocytes Responsive to the Growth-Promoting Activities of Adenoviral E1A

2001 • 37 citations

Overexpression of long or short FGFR-1 results in FGF-2-mediated proliferation in neonatal cardiac myocyte cultures

1999 • 36 citations

Novel Cell Lines Promote the Discovery of Genes Involved in Early Heart Development

2001 • 36 citations

Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis

1997 • 33 citations

Identification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice

1993 • 33 citations

Epidermal Growth Factor Promotes a Cardiomyoblastic Phenotype in Human Fetal Cardiac Myocytes

1996 • 32 citations

Inhibition of Cardiac Myocyte Division in c-mycTransgenic Mice

1997 • 31 citations

Formation of Fetal Rat Cardiac Cell Clones by Retroviral Transformation: Retention of Select Myocyte Characteristics

1993 • 27 citations

Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation

2001 • 27 citations

Developmental Expression of p107 mRNA and Evidence for Alternative Splicing of the p107 (RBL1) Gene Product

1995 • 26 citations

Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice.

1994 • 22 citations

Factors altering DNA synthesis in the cardiac myocyte of the adult newt, Notophthalmus viridescens

1994 • 22 citations

Functional Abrogation of p53 is Required for T-Ag Induced Proliferation in Cardiomyocytes

2001 • 21 citations

[Proliferation dynamics of cellular elements in the differentiating mouse myocardium].

1968 • 21 citations

Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product

1997 • 20 citations

Postnatal DNA synthesis in hearts of mice: autoradiographic and cytofluorometric investigations

1988 • 16 citations

Behavior of embryonic chick heart cells in culture. 1. Cellular responses to insulin-transferrin-selenium

1993 • 16 citations

Rapamycin (Sirolimus) Inhibits Heart Cell Growth In Vitro

1998 • 11 citations

Transformation of adult ventricular myocytes with the temperature sensitive A58 (tsA58) mutant of the SV40 large T antigen

1994 • 9 citations

Function of FK506 binding protein (FKBP) in chick embryonic cardiac development.

1997 • 8 citations

[The proliferation and DNA synthesis during early stages of myocardial development].

1968 • 6 citations