The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

The structure and function of the homeodomain

1989 • 1,007 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

1993 • 790 citations

Homeodomain-DNA recognition

1994 • 784 citations

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

1993 • 719 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

1990 • 545 citations

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

1993 • 533 citations

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.

1994 • 518 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.

1994 • 310 citations

Drosophila NK-homeobox genes.

1989 • 300 citations

Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain

1992 • 291 citations

Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5

1995 • 289 citations

Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias in Mice

1988 • 275 citations

A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.

1994 • 271 citations

Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice.

1995 • 241 citations

Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis.

1987 • 234 citations

XNkx-2.5, a Xenopus Gene Related to Nkx-2.5 and tinman: Evidence for a Conserved Role in Cardiac Development

1994 • 219 citations

Muscle Creatine Kinase Sequence Elements Regulating Skeletal and Cardiac Muscle Expression in Transgenic Mice

1989 • 204 citations

The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle

1994 • 200 citations

Duplicated CArG Box Domains Have Positive and Mutually Dependent Regulatory Roles in Expression of the Human α-Cardiac Actin Gene

1987 • 192 citations

The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.

1994 • 186 citations

Complete sequence and organization of the human cardiac β-myosin heavy chain gene

1990 • 131 citations

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman

1995 • 126 citations

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression.

1992 • 123 citations

vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein.

1995 • 122 citations

In vivo analysis of the murine beta-myosin heavy chain gene promoter.

1993 • 120 citations

Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription.

1994 • 114 citations

The gene for rat atrial natriuretic factor.

1985 • 113 citations

Redundant Domains Contribute to the Transcriptional Activity of the Thyroid Transcription Factor 1

1995 • 111 citations

Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.

1994 • 109 citations

Different Regulatory Sequences Control Creatine Kinase-M Gene Expression in Directly Injected Skeletal and Cardiac Muscle

1993 • 91 citations

In situ analysis of the cardiac muscle gene program during embryogenesis

1994 • 85 citations

The nucleotide sequence of a rat myosin light chain 2 gene

1984 • 83 citations

Lox10, a member of the NK-2 homeobox gene class, is expressed in a segmental pattern in the endoderm and in the cephalic nervous system of the leech Helobdella

1993 • 74 citations

A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.

1993 • 70 citations

Planarian homeobox genes: cloning, sequence analysis, and expression.

1991 • 69 citations

Genomic organization and expression of the planarian homeobox genes Dth-1 and Dth-2

1993 • 61 citations

Heart-specific targeting of firefly luciferase by the myosin light chain-2 promoter and developmental regulation in transgenic mice.

1993 • 60 citations

An M-CAT Binding Factor and an RSRF-Related A-Rich Binding Factor Positively Regulate Expression of the α-Cardiac Myosin Heavy-Chain Gene In Vivo

1994 • 59 citations

fos/jun Repression of Cardiac-Specific Transcription in Quiescent and Growth-Stimulated Myocytes is Targeted at a Tissue-Specific cis element

1993 • 54 citations

Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1.

1995 • 47 citations

The avian cardiac alpha-actin promoter is regulated through a pair of complex elements composed of E boxes and serum response elements that bind both positive- and negative-acting factors.

1994 • 45 citations

Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism.

1993 • 43 citations

cis-Dominance of rat atrial natriuretic factor gene regulatory sequences in transgenic mice

1991 • 41 citations

Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart.

1993 • 37 citations

A single transcription factor binds to two divergent sequence elements with a common function in cardiac myosin light chain-2 promoter.

1992 • 27 citations

Definition of the DNA-Binding Specificity of TTF-1 Homeodomain by Chromatographic Selection of Binding Sequences

1995 • 17 citations