Bench to Bedside Nitric Oxide in Emergency Medicine

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Increased nitric oxide in exhaled air of asthmatic patients

1994 • 1,462 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Harrison's Principles of Internal Medicine

1994 • 1,392 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Increased amount of nitric oxide in exhaled air of asthmatics

1993 • 1,252 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Nitric Oxide: A Physiologic Messenger

1994 • 915 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

New Horizons

1979 • 624 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

1991 • 538 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Inhaled Nitric Oxide Selectively Reverses Human Hypoxic Pulmonary Vasoconstriction without Causing Systemic Vasodilation

1993 • 459 citations

Nitric oxide in septic shock

1999 • 452 citations

Role of Neutrophils in Myocardial Ischemia and Reperfusion

1995 • 431 citations

Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations

1997 • 400 citations

Time‐course and dose‐response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome

1993 • 396 citations

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

1994 • 369 citations

Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions.

1992 • 339 citations

The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery

1998 • 334 citations

Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.

1995 • 329 citations

The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.

1992 • 323 citations

Nitric oxide and septic shock

1997 • 309 citations

Nitric oxide as a signal in blood vessels

1992 • 285 citations

Prolonged Inhalation of Low Concentrations of Nitric Oxide in Patients with Severe Adult Respiratory Distress Syndrome

1994 • 282 citations

Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.

1995 • 276 citations

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.

1993 • 274 citations

Leukocyte—endothelial cell interactions

1992 • 246 citations

Mechanisms of Reperfusion Injury

1994 • 234 citations

Mechanisms of peroxynitrite-induced injury to pulmonary surfactants

1993 • 232 citations

Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide‐Dependent Cerebral Injury^a

1994 • 215 citations

Inhibition of Platelet Aggregation by Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

1995 • 210 citations

L-arginine

1995 • 208 citations

Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation.

1996 • 187 citations

Pathophysiology and Treatment of Septic Shock

1991 • 172 citations

Inhibition by nitric oxide‐donors of human polymorphonuclear leucocyte functions

1993 • 161 citations

[60] Antioxidant effectiveness in ischemia-reperfusion tissue injury

1994 • 159 citations

Nitric oxide and septic shock.

1996 • 159 citations

Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans

1996 • 155 citations

Signal Transduction Using Nitric Oxide and Cyclic Guanosine Monophosphate

1996 • 150 citations

Rheologic predictors of the severity of the painful sickle cell crisis

1988 • 148 citations

Mechanisms of vasodilation

1983 • 148 citations

Inhaled Nitric Oxide in Sickle Cell Disease with Acute Chest Syndrome

1997 • 146 citations

Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

1997 • 139 citations

Methylene blue increases systemic vascular resistance in human septic shock

1992 • 132 citations

Effectiveness of Nitric Oxide Inhalation in Septic ARDS

1996 • 131 citations

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

1992 • 130 citations

The sickle cell diseases. Clinical manifestations including the "sickle crisis".

1974 • 129 citations

Peroxynitrite Inactivates Thiol-Containing Enzymes of Trypanosoma cruzi Energetic Metabolism and Inhibits Cell Respiration

1994 • 126 citations

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

1997 • 123 citations

Nitric Oxide and Septic Shock

1996 • 118 citations

Peroxynitrite-induced cardiac myocyte injury

1996 • 111 citations

Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells

1994 • 111 citations

Supplemental l-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury

1995 • 108 citations

Inhaled Nitric Oxide Reduces Pulmonary Transvascular Albumin Flux in Patients with Acute Lung Injury

1995 • 100 citations

Nitric oxide as a neurotransmitter in human airways.

1995 • 95 citations

Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury.

1997 • 93 citations

Simultaneous generation of nitric oxide and superoxide by inflammatory cells in rats

1995 • 93 citations

Leukocyte-endothelial cell interactions.

1993 • 92 citations

Nitric oxide and shock

1997 • 87 citations

Nitric oxide is an antiadhesive molecule for leukocytes.

1995 • 86 citations

Inhaled nitric oxide: clinical applications, indications, and toxicology

1997 • 85 citations

Arrest of endotoxin-induced hypotension by transforming growth factor beta1.

1996 • 84 citations

Measurement of blood volume using indocyanine green measured with pulse-spectrophotometry

1998 • 83 citations

Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats

1997 • 76 citations

Hospital mortality in acute myocardial infarction in the era of reperfusion therapy (the myocardial infarction triage and intervention project)

1993 • 75 citations

NITRIC OXIDE AND THE KIDNEY

1993 • 74 citations

Inhaled Nitric Oxide Therapy

1995 • 73 citations

The metabolites of nitric oxide in sickle‐cell disease

1995 • 71 citations

Selective iNOS Inhibition Is Superior to Norepinephrine in the Treatment of Rat Endotoxic Shock

1998 • 67 citations

Cellular, biochemical, and molecular aspects of reperfusion injury

1994 • 63 citations

Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis.

1994 • 61 citations

Endothelium-derived nitric oxide attenuates neutrophil adhesion to endothelium under arterial flow conditions.

1994 • 60 citations

Nitric Oxide Metabolite Levels in Acute Vaso‐occlusive Sickle‐cell Crisis

1996 • 56 citations

Inhibition of endothelium-dependent vasorelaxation by sickle erythrocytes

1993 • 52 citations

Hemoglobin-Based Oxygen Carriers: Development and Clinical Potential

1999 • 48 citations

Nitric Oxide Mitigates Leukocyte Adhesion and Vascular Leak After Myocardial Ischemia

1996 • 48 citations

Protection of Ischemia-Reperfusion Injury by Sydnonimine NO Donors via Inhibition of Neutrophil-Endothelium Interaction

1993 • 46 citations

New approaches to acute lung injury

1996 • 44 citations

Endothelium-derived nitric oxide attenuates neutrophil adhesion to endothelium under arterial flow conditions.

1994 • 41 citations

Role of <scp>l</scp>‐arginine in preventing myocardial and endothelial injury following ischaemia/reperfusion in the rat isolated heart

1996 • 41 citations

Reperfusion Injuries and Clinical Capillary Leak Syndrome

1995 • 40 citations

Supplement of Nitric Oxide Attenuates Neutrophil-Mediated Reperfusion Injury

1995 • 38 citations

PULMONARY HYPERTENSION AND REDUCED CARDIAC OUTPUT DURING INHIBITION OF NITRIC OXIDE SYNTHESIS IN HUMAN SEPTIC SHOCK

1998 • 37 citations

Leukocyte adhesion in ischemia/reperfusion.

1993 • 34 citations

Reperfusion injuries and clinical capillary leak syndrome

1994 • 33 citations

NG-monomethyl-L-arginine improves survival in a pig model of abdominal sepsis

1998 • 31 citations

The sickle cell diseases. Clinical manifestations including the "sickle crisis"

1974 • 28 citations

Inhibition of Platelet Aggregation by Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

1996 • 23 citations

S-Nitroso-N-acetylpenicillamine is a Potent Inhibitor of Neutrophil-Endothelial Interaction

1993 • 22 citations

Introduction

1994 • 21 citations

LACK OF PROTECTION BY Nw-METHYL-L-ARGININE (NMA), A NITRIC OXIDE SYNTHASE INHIBITOR, IN ENDOTOXIN (LPS)-CHALLENGED CANINES

1993 • 21 citations

Modulation of neutrophil activity by nitric oxide during acute myocardial ischaemia and reperfusion

1994 • 19 citations

Physiologic Determinants of the Response to Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

1998 • 16 citations

Nitric oxide, sepsis and liver metabolism

1997 • 15 citations

Structural and Functional Alterations of Surfactant Protein A by Peroxynitrite

1994 • 13 citations

Clinical Implications of Hemoglobin as a Nitric Oxide Carrier

1999 • 9 citations

NO in Septic Shock

1997 • 6 citations