Clinical Implications of Hemoglobin as a Nitric Oxide Carrier

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient

1997 • 1,050 citations

Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia.

1989 • 935 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.

1995 • 783 citations

Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome

1998 • 754 citations

Tumor necrosis factor in the heart

1998 • 751 citations

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

1999 • 420 citations

Migration of smooth muscle and endothelial cells. Critical events in restenosis.

1992 • 406 citations

The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery

1998 • 334 citations

Molecular biology of nitric oxide synthases.

1998 • 326 citations

In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.

1994 • 290 citations

Inhaled Nitric Oxide Versus Conventional Therapy

1998 • 271 citations

Nitric Oxide Synthases and Cardiac Muscle

1997 • 259 citations

Early Endothelial Dysfunction Predicts the Development of Transplant Coronary Artery Disease at 1 Year Posttransplant

1996 • 254 citations

Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.

1997 • 247 citations

Efficient Inhibition of Intimal Hyperplasia by Adenovirus-Mediated Inducible Nitric Oxide Synthase Gene Transfer to Rats and Pigs in Vivo

1998 • 233 citations

Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.

1995 • 229 citations

Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

1997 • 139 citations

Requirements for therapeutic inhibition of sickle haemoglobin gelation

1978 • 138 citations

Nitric oxide, the biological mediator of the decade: fact or fiction?

1997 • 125 citations

Clinical Development of Human Polymerized Hemoglobin as a Blood Substitute

1996 • 123 citations

Chronic Inhalation of Nitric Oxide Inhibits Neointimal Formation After Balloon-Induced Arterial Injury

1996 • 113 citations

Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients.

1992 • 91 citations

Albumin Is an Important Vascular Tonus Regulator as a Reservoir of Nitric Oxide

1996 • 82 citations

Beneficial effect of SPM-5185, a cysteine-containing nitric oxide donor, in rat carotid artery intimal injury.

1994 • 81 citations

Inhaled Nitric Oxide Variably Improves Oxygenation and Pulmonary Hypertension in Patients with Acute Respiratory Distress Syndrome

1995 • 75 citations

Stereochemistry of carbon monoxide binding to normal human adult and Cowtown haemoglobins

1990 • 65 citations

Effects of exposure of blood hemoglobin to nitric oxide

1985 • 55 citations

Yohimbine modulates diaspirin crosslinked hemoglobin-induced systemic hemodynamics and regional circulatory effects

1995 • 51 citations

EVIDENCE THAT GRAFT CORONARY ARTERIOSCLEROSIS BEGINS IN THE EARLY PHASE AFTER TRANSPLANTATION AND PROGRESSES WITHOUT CHRONIC IMMUNOREACTION

1995 • 50 citations

Hemoglobin-Based Oxygen Carriers: Development and Clinical Potential

1999 • 48 citations

Nitric oxide and cardiac failure

1997 • 39 citations

Enhanced renal allograft rejection by inhibitors of nitric oxide synthase: a nonimmunologic influence on alloreactivity.

1996 • 36 citations

Effect of nitric oxide on the oxygen transport of human erythrocytes

1977 • 32 citations

NITRIC OXIDE SYNTHASE INHIBITION IS ASSOCIATED WITH DECREASED SURVIVAL OF CARDIAC ALLOGRAFTS IN THE RAT1

1996 • 27 citations

Evidence that graft coronary arteriosclerosis begins in the early phase after transplantation and progresses without chronic immunoreaction

1996 • 23 citations

Possible dual role of nitric oxide in oxidative stress injury: A study in perfused hepatocytes

1997 • 15 citations