Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

1991 • 1,134 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Clinical risks for development of the acute respiratory distress syndrome.

1995 • 884 citations

Leukocyte-endothelial interactions

1985 • 834 citations

A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis

1991 • 741 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

State of the Art

1983 • 655 citations

Leukocyte-endothelial interactions

1985 • 635 citations

Alterations of the Gas Exchange Apparatus in Adult Respiratory Insufficiency Associated with Septicemia^1,2

1977 • 551 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

1987 • 417 citations

Materials constants of KNbO3 relevant for electro- and acousto-optics

1993 • 331 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

The Risk Factors, Incidence, and Prognosis of ARDS following Septicemia

1983 • 254 citations

Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange

1993 • 161 citations

A sensitive protein assay method using micro-titer plates

1986 • 161 citations

The Mortality of Hospital-Acquired Bloodstream Infections: Need for a New Vital Statistic?

1988 • 152 citations

Anti-CD18 antibody attenuates neutropenia and alveolar capillary-membrane injury during gram-negative sepsis.

1991 • 116 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

Introduction of new technology into critical care practice

1993 • 69 citations

Host responses in mediating sepsis and adult respiratory distress syndrome.

1990 • 65 citations

Efficacy of Inhaled Nitric Oxide in a Porcine Model of Adult Respiratory Distress Syndrome

1994 • 64 citations

Experimental and clinical assessment of lung injury by measurement of extravascular lung water and transcapillary protein flux in ARDS: A review of current techniques

1988 • 34 citations

Effects of ibuprofen on a porcine model of acute respiratory failure

1984 • 34 citations

Ibuprofen attenuates hypochlorous acid production from neutrophils in porcine acute lung injury

1990 • 32 citations

Delayed Cyclo-oxygenase Blockade Reduces the Neutrophil Respiratory Burst and Plasma Tumor Necrosis Factor Levels in Sepsis-Induced Acute Lung Injury

1991 • 30 citations

The neutrophil respiratory burst and tissue injury in septic acute lung injury: the effect of cyclooxygenase inhibition in swine.

1992 • 28 citations

The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model

1994 • 27 citations

Effects of ibuprofen on a pig Pseudomonas ARDS model

1986 • 26 citations

Pulmonary compliance: early assessment of evolving lung injury after onset of sepsis

1990 • 20 citations

CIRCULATORY AND VENTILATORY EFFECTS OF INTERMITTENT NITRIC OXIDE INHALATION DURING PORCINE ENDOTOXEMIA

1994 • 19 citations