Role of Neutrophils in Myocardial Ischemia and Reperfusion

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

The acute phase response

1994 • 2,927 citations

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

1980 • 2,722 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Circulating adhesion molecules in disease

1993 • 1,425 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

1992 • 1,255 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 962 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

Selectins.

1993 • 869 citations

Control of vascular permeability by polymorphonuclear leukocytes in inflammation

1981 • 850 citations

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.

1983 • 845 citations

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 • 823 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

PLATELET ACTIVATING FACTOR: A BIOLOGICALLY ACTIVE PHOSPHOGLYCERIDE

1986 • 781 citations

The cardiac effects of adenosine

1989 • 779 citations

The speed of healing of myocardial infarction

1939 • 761 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

A form of circulating ICAM-1 in human serum.

1991 • 700 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries

1989 • 612 citations

Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils.

1991 • 605 citations

Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF

1989 • 602 citations

Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils.

1991 • 600 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Leucocyte-endothelial interactions and regulation of leucocyte migration

1994 • 584 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Leukocytes and the Risk of Ischemic Diseases

1987 • 525 citations

Chemotactic activity of elastin-derived peptides.

1980 • 519 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Elastase in Tissue Injury

1985 • 512 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Role of leukocytes in response to acute myocardial ischemia and reflow in dogs

1986 • 507 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

The Leukocyte Count as a Predictor of Myocardial Infarction

1974 • 474 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro.

1991 • 439 citations

Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils.

1990 • 421 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

Inflammation in the course of early myocardial ischemia

1991 • 388 citations

THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS

1971 • 388 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.

1993 • 352 citations

Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils.

1994 • 334 citations

Reperfusion induced injury: manifestations, mechanisms, and clinical relevance

1992 • 326 citations

The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.

1992 • 323 citations

Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury.

1989 • 308 citations

Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence.

1992 • 304 citations

Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion.

1991 • 302 citations

Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.

1991 • 296 citations

Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion.

1992 • 296 citations

Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes.

1982 • 292 citations

Mediation of Cardioprotection by Transforming Growth Factor-β

1990 • 292 citations

Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor.

1987 • 292 citations

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.

1986 • 283 citations

Neutrophil function in ischemic heart disease.

1989 • 278 citations

Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.

1988 • 278 citations

Deleterious effects of methylprednisolone in patients with myocardial infarction.

1976 • 275 citations

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

1978 • 264 citations

Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.

1985 • 262 citations

Human neutrophil-derived platelet activating factor.

1980 • 260 citations

Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction.

1994 • 256 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Leukocyte—endothelial cell interactions

1992 • 246 citations

Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia

1978 • 241 citations

Neutrophils as potential participants in acute myocardial ischemia: Relevance to reperfusion

1988 • 240 citations

Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium.

1986 • 240 citations

Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion

1986 • 238 citations

Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium.

1993 • 238 citations

Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

1982 • 237 citations

Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.

1992 • 234 citations

Thromboxane generation by human peripheral blood polymorphonuclear leukocytes.

1978 • 229 citations

Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium.

1993 • 228 citations

Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway.

1983 • 222 citations

Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism.

1990 • 217 citations

The role of the neutrophil and free radicals in ischemic myocardial injury

1989 • 214 citations

Effect of Pentoxifylline on the Phagocytic Activity, cAMP Levels, and Superoxide Anion Production by Monocytes and Polymorphonuclear Cells

1986 • 214 citations

Developmentally Regulated Systemic Endopolyploidy in Succulents with Small Genomes

1990 • 204 citations

Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle. A possible initiator of an extra myocardial mechanism of ischemic injury.

1985 • 203 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

Elevated plasma interleukin-6 levels in patients with acute myocardial infarction

1993 • 201 citations

Endothelial cell killing by neutrophils. Synergistic interaction of oxygen products and proteases.

1989 • 199 citations

The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction.

1982 • 199 citations

Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart.

1987 • 197 citations

Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion.

1992 • 196 citations

Human neutrophil degranulation during extracorporeal circulation

1987 • 194 citations

Reperfusion injury

1988 • 191 citations

Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction

1990 • 186 citations

Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period.

1991 • 183 citations

Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo

1984 • 182 citations

Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation.

1992 • 174 citations

Sialyl Lewisx-containing oligosaccharide attenuates myocardial reperfusion injury in cats.

1994 • 174 citations

Complement Localization and Mediation of Ischemic Injury in Baboon Myocardium

1980 • 172 citations

Circulating tumour necrosis factor‐α (cachectin) in myocardial infarction

1989 • 172 citations

Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury.

1988 • 171 citations

Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model.

1989 • 170 citations

Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical.

1987 • 169 citations

Role of endothelial leukocyte adhesion molecule-1 and platelet-activating factor in neutrophil adherence to IL-1-prestimulated endothelial cells. Endothelial leukocyte adhesion molecule-1-mediated CD18 activation.

1991 • 168 citations

Chemokines and serpentines: the molecular biology of chemokine receptors

1993 • 167 citations

Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1.

1991 • 162 citations

Interaction of neutrophils with vascular smooth muscle: identification of a neutrophil-derived relaxing factor.

1988 • 160 citations

Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase.

1980 • 159 citations

Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation

1987 • 159 citations

Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation.

1993 • 156 citations

Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo.

1988 • 154 citations

Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function.

1990 • 154 citations

Granulocytes and Phorbol Myristate Acetate Increase Permeability to Albumin of Cultured Endothelial Monolayers and Isolated Perfused Lungs

1983 • 152 citations

Rapid induction of neutrophil–endothelial adhesion by endothelial complement fixation

1989 • 150 citations

Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion.

1987 • 149 citations

Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion.

1991 • 149 citations

Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury.

1993 • 140 citations

Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

1984 • 140 citations

Presence of circulating endotoxins during cardiac operations

1987 • 139 citations

Nafazatrom-induced salvage of ischemic myocardium in anesthetized dogs is mediated through inhibition of neutrophil function.

1985 • 137 citations

Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide-generating system

1980 • 134 citations

Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary arteriography

1984 • 133 citations

Evidence of Polymorphonuclear Neutrophils (PMN) Activation in Patients With Insulin-Dependent Diabetes Mellitus

1987 • 131 citations

Consequences of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia.

1987 • 130 citations

White blood cell count, coronary heart disease, and death: The NHANES I Epidemiologic Follow-up Study

1993 • 129 citations

The role of neutrophils and free radicals in the ischemic-reperfused heart: Why the confusion and controversy?

1989 • 129 citations

The complement system in ischemic heart disease.

1990 • 126 citations

The complement system in myocardial ischaemia/reperfusion injury

1994 • 126 citations

Plasma levels of main granulocyte components during cardiopulmonary bypass

1988 • 125 citations

Mechanism of the cardioprotective effect of transforming growth factor beta 1 in feline myocardial ischemia and reperfusion.

1993 • 122 citations

White Blood Cell Count and Haematocrit as Predictors of Coronary Recurrence after Myocardial Infarction

1985 • 119 citations

Reduced neutrophil superoxide anion release after prolonged infusions of lidocaine.

1985 • 118 citations

Kinetics of C5a release in cardiac lymph of dogs experiencing coronary artery ischemia-reperfusion injury.

1992 • 116 citations

Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs.

1993 • 115 citations

Interleukin 6 primes human neutrophil and monocyte oxidative burst response

1989 • 115 citations

Granulocyte activation after coronary angioplasty in humans.

1990 • 113 citations

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

1985 • 111 citations

The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations

1983 • 111 citations

Leukocytes and the risk of ischemic diseases

1987 • 109 citations

Cardiac dysfunction caused by purified human C3a anaphylatoxin.

1985 • 108 citations

Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion.

1988 • 107 citations

Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion.

1990 • 106 citations

Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence.

1991 • 105 citations

Canine neutrophil activation by cardiac lymph obtained during reperfusion of ischemic myocardium.

1989 • 105 citations

Effects of Cardiopulmonary Bypass on Pulmonary Leukostasis and Complement Activation

1988 • 105 citations

Activation of the complement system by recombinant tissue plasminogen activator

1987 • 104 citations

Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass

1989 • 104 citations

Increased oxygen free radical activity in patients on cardiopulmonary bypass undergoing aortocoronary bypass surgery

1992 • 103 citations

Coronary constriction by leukotriene C4, D4, and E4 in the intact pig heart

1983 • 103 citations

Effects of complement activation in the isolated heart. Role of the terminal complement components.

1992 • 102 citations

Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion

1989 • 102 citations

Collagenolytic metalloenzymes of the human neutrophil

1986 • 102 citations

The white blood cell count and risk for coronary heart disease

1992 • 99 citations

Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor.

1988 • 96 citations

Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion.

1991 • 95 citations

Detection of the terminal complement complex in patient plasma following acute myocardial infarction

1988 • 94 citations

Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.

1993 • 94 citations

Effect of methylprednisolone on endotoxemia and complement activation during cardiac surgery

1989 • 93 citations

Effect of BW755C in an occlusion-reperfusion model of ischemic myocardial injury

1983 • 92 citations

Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart

1986 • 90 citations

Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury.

1993 • 90 citations

Stimulus-Specific Effects of Pentoxifylline on Neutrophil CR3 Expression, Degranulation, and Superoxide Production

1990 • 87 citations

Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man

1988 • 83 citations

Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart.

1994 • 82 citations

Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.

1990 • 82 citations

Lack of effect of aspirin on myocardial infarct size in the dog

1981 • 74 citations

Singlet oxygen and myocardial injury: Ultrastructural, cytochemical and electrocardiographic consequences of photoactivation of rose bengal

1990 • 73 citations

Demonstration of myocardial reperfusion injury in humans: Results of a pilot study utilizing acute coronary angioplasty with perfluorochemical in anterior myocardial infarction

1991 • 72 citations

Chemotactic activity generated in human serum from the fifth component of complement by hydrogen peroxide.

1984 • 70 citations

Calcium channel antagonist induced inhibition of superoxide production in human neutrophils

1986 • 70 citations

Activated neutrophils aggravate endothelial dysfunction after reperfusion of the ischemic feline myocardium

1992 • 69 citations

The Effects of Aminophylline and Pentoxifylline on Multiple Organ Damage afterEscherichia coliSepsis

1989 • 69 citations

The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculaturein vitro andin vivo

1991 • 67 citations

Detection of leukotriene B4 in cardiac tissue and its role in infarct extension through leucocyte migration

1988 • 67 citations

Reduction of experimental canine myocardial infarct size with prostaglandin E1: inhibition of neutrophil migration and activation.

1988 • 64 citations

Heparin inhibition of polymorphonuclear leukocyte activation in vitro. A possible pharmacological approach to granulocyte-mediated vascular damage

1984 • 63 citations

Influence of leukopenia on collateral flow, reperfusion flow, reflow ventricular fibrillation, and infarct size in dogs

1989 • 61 citations

Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells

1992 • 52 citations

Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs.

1990 • 50 citations

Preservation of endothelial cell structure and function by intracoronary perfluorochemical in a canine preparation of reperfusion.

1987 • 49 citations

Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats.

1990 • 49 citations

Release of phospholipase A2 activity from rabbit peritoneal neutrophils by f-Met-Leu-Phe.

1983 • 46 citations

Severe neutrophil depletion by leucocyte filters or cytotoxic drug does not improve recovery of contractile function in stunned porcine myocardium

1993 • 46 citations

The leukergy test in patients with ischemic heart disease

1986 • 45 citations

Effects of leukocyte activation on myocardial vascular resistance.

1990 • 45 citations

Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells.

1993 • 44 citations

Early and late effects of leukopenic reperfusion on the recovery of cardiac contractile function. Studies in the transplanted and isolated blood-perfused rat heart.

1993 • 44 citations

Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.

1990 • 39 citations

Permeability properties of rat renal lysosomes

1994 • 38 citations

Platelet-derived growth factor stimulates phagocytosis and blocks agonist-induced activation of the neutrophil oxidative burst: a possible cellular mechanism to protect against oxygen radical damage.

1987 • 37 citations

Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration

1993 • 36 citations

Reduction in myocardial neutrophil accumulation and infarct size following administration of thromboxane inhibitor U-63,557A

1987 • 36 citations

Pentoxifylline does not act via adenosine receptors in the inhibition of the superoxide anion production of human polymorphonuclear leukocytes

1991 • 36 citations

Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs

1990 • 35 citations

Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.

1992 • 34 citations

Neutrophil oxidants inactivate alpha-1-protease inhibitor and promote PMN-mediated detachment of cultured endothelium. Protection by free methionine.

1986 • 33 citations

Abrupt complement activation and transient neutropenia in patients with acute myocardial infarction treated with streptokinase.

1994 • 32 citations

Studies of controlled reperfusion after ischemia. XXII. Reperfusate composition: effects of leukocyte depletion of blood and blood cardioplegic reperfusates after acute coronary occlusion.

1991 • 32 citations

Role of cellular proteinases in acute myocardial infarction I. proteolysis in nonischemic and ischemic rat myocardium and the effects of antipain, leupeptin, pepstatin and chymostatin administered in vivo

1983 • 32 citations

Role of perfluorochemical emulsions in the treatment of myocardial reperfusion injury

1992 • 32 citations

Coronary and myocardial effects of activated neutrophils in perfused rabbit hearts.

1986 • 32 citations

Role of free radicals and neutrophils in canine myocardial reperfusion injury: myocardial salvage by a novel free radical scavenger, 2-octadecylascorbic acid

1989 • 31 citations

Novel aspects of inflammation: interleukin-8 and related chemotactic cytokines

1993 • 31 citations

Anti-ischaemic and endothelial protective actions of recombinant human osteogenic protein (hOP-1)

1992 • 30 citations

Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical.

1990 • 30 citations

Functional impairment in isolated rat hearts induced by activated leukocytes: Protective effect of oxygen free radical scavengers

1989 • 30 citations

Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: Beneficial effects on myocardial histology

1991 • 29 citations

Increased neutrophil aggregability in coronary artery disease

1990 • 29 citations

Captopril--a potential free radical scavenger: inhibition of PMN NADPH oxidase.

1988 • 29 citations

Neutrophil mediated damage to isolated myocytes after anoxia and reoxygenation

1994 • 27 citations

Effect of antibody to leukocyte adhesion molecule CD18 on recovery of neonatal lamb hearts after 2 hours of cold ischemia.

1992 • 27 citations

Limitation of no reflow injury by blood-free reperfusion with oxygenated perfluorochemical (fluosol-DA 20%)

1991 • 26 citations

Role of invading leukocytes in enhanced atrial eicosanoid production following rabbit left ventricular myocardial infarction.

1989 • 25 citations

Studies of controlled reperfusion after ischemia

1991 • 25 citations

Leukotrienes D4 and E4 produced in myocardium impair coronary flow and ventricular function after two hours of global ischaemia in rat heart

1993 • 25 citations

Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension

1991 • 24 citations

Thromboxane B2 in cardiac lymph. Effect of superoxide dismutase and catalase during myocardial ischemia and reperfusion.

1990 • 23 citations

Thrombolytic treatment in acute myocardial infarction: neutrophil activation, peripheral leucocyte responses, and myocardial injury.

1991 • 23 citations

Arachidonic acid monooxygenase and lipoxygenase activities in polymorphonuclear leukocytes

1987 • 22 citations

Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.

1993 • 22 citations

The acute inflammatory response to myocardial infarction: imaging with indium-111 labelled autologous neutrophils.

1987 • 21 citations

Coronary vascular injury due to ischemia-reperfusion is reduced by pentoxifylline.

1992 • 19 citations

Generation of biologically active, complement-(C5) derived peptides by cathepsin H.

1983 • 19 citations

Pentoxifylline does not attenuate acute lung injury in the absence of granulocytes

1991 • 18 citations

Neutrophil depletion fails to modify myocardial no reflow and functional recovery after coronary reperfusion

1989 • 18 citations

Transcardiac release of leukotriene C4by neutrophils in patients with coronary artery disease

1991 • 16 citations

Role of cellular proteinases in acute myocardial infarction II. influence of in vivo suppression of myocardial proteolysis by antipain, leupeptin and pepstatin on myocardial infarct size in the rat

1983 • 14 citations

Pentoxifylline inhibits actin polymerization in human neutrophils after stimulation by chemoattractant factor

1990 • 11 citations

Effect of Streptokinase on Human Neutrophil Function in Vitro and in Patients with Acute Myocardial Infarction

1994 • 10 citations

Effect of a critical coronary stenosis on myocardial neutrophil accumulation during ischemia and early reperfusion in dogs.

1989 • 9 citations

Fibrin (ogen)-derived peptide Bβ 30–43 is a sensitive marker of activated neutrophils during fibrinolytic-treated acute myocardial infarction in man

1992 • 7 citations

Leucocyte depletion attenuates the early increase in myocardial capillary permeability to small hydrophilic solutes following ischaemia and reperfusion

1993 • 5 citations

Persistent Cardioprotection by Azapropazone in a Canine Model of Coronary Artery Thrombosis and Thrombolysis

1991 • 4 citations

Effect of 5-aminosalicylic acid on myocardial capillary permeability following ischaemia and reperfusion

1992 • 1 citations