Modulation of neutrophil activity by nitric oxide during acute myocardial ischaemia and reperfusion

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Role of endothelium in responses of vascular smooth muscle.

1983 • 1,975 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemie myocardium

1985 • 994 citations

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.

1983 • 845 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Leukocyte-endothelial interactions

1985 • 834 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

Leukocyte-endothelial interactions

1985 • 635 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

Nitric oxide modulates microvascular permeability

1992 • 564 citations

An approach to free radicals in medicine and biology.

1980 • 548 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Role of leukocytes in response to acute myocardial ischemia and reflow in dogs

1986 • 507 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.

1990 • 471 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

1990 • 456 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

1981 • 380 citations

Endothelium‐derived relaxing factor inhibits in vitro platelet aggregation

1987 • 367 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro.

1987 • 358 citations

Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia

1991 • 351 citations

Nitric oxide: a pathogenetic factor in autoimmunity

1992 • 342 citations

Coronary Vascular Reactivity After Acute Myocardial Ischemia

1982 • 336 citations

Nonspecific defence mechanism: the role of nitric oxide

1991 • 325 citations

The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.

1992 • 323 citations

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

1980 • 313 citations

Myocardial ischemia revisited. The osmolar load, membrane damage, and reperfusion

1986 • 313 citations

Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury.

1989 • 308 citations

Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion.

1991 • 302 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.

1991 • 296 citations

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.

1993 • 274 citations

Neutrophils as potential participants in acute myocardial ischemia: Relevance to reperfusion

1988 • 240 citations

Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.

1992 • 234 citations

Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog.

1987 • 231 citations

Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion

1991 • 217 citations

The role of the neutrophil and free radicals in ischemic myocardial injury

1989 • 214 citations

Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts

1990 • 204 citations

Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size

1992 • 184 citations

Endothelial control of vascular tone in large and small coronary arteries

1990 • 184 citations

Nitric oxide takes centre-stage with newly defined roles

1992 • 174 citations

Reperfusion injury: laboratory artifact or clinical dilemma?

1986 • 174 citations

Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function.

1990 • 154 citations

Nitric oxide and neurons

1992 • 152 citations

Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion.

1987 • 149 citations

Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion.

1989 • 146 citations

Role of endogenous nitric oxide in septic shock.

1993 • 131 citations

The role of neutrophils and free radicals in the ischemic-reperfused heart: Why the confusion and controversy?

1989 • 129 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells.

1990 • 125 citations

Changes in the microvasculature of ischemic and infarcted myocardium.

1975 • 124 citations

Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling.

1975 • 123 citations

Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs.

1993 • 115 citations

Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion.

1988 • 107 citations

Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs

1992 • 107 citations

Hormonal Control of Lysosomal Enzyme Release from Human Neutrophils: Elevation of Cyclic Nucleotide Levels by Autonomic Neurohormones

1974 • 102 citations

Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion

1989 • 102 citations

Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery.

1991 • 98 citations

Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion.

1991 • 95 citations

Protection by superoxide dismutase from myocardial dysfunction and attenuation of vasodilator reserve after coronary occlusion and reperfusion in dog.

1989 • 92 citations

Release of NO and EDRF from cultured bovine aortic endothelial cells

1989 • 86 citations

Rabbit polymorphonuclear neutrophils elicit endothelium-dependent contraction in vascular smooth muscle.

1989 • 85 citations

Alleviation of myocardial stunning by leukocyte and platelet depletion.

1989 • 85 citations

Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release.

1991 • 84 citations

Myeloperoxidase Activity as a Quantitative Marker of Polymorphonuclear Leukocyte Accumulation into an Experimental Myocardial Infarct—The Effect of Ibuprofen on Infarct Size and Polymorphonuclear Leukocyte Accumulation

1985 • 72 citations

Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines.

1989 • 72 citations

Influence of neutrophil depletion on myocardial function and flow after reversible ischemia

1989 • 68 citations

Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes

1990 • 60 citations

Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: Role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins

1988 • 57 citations

Myocardial Salvage Induced by REV-5901

1987 • 57 citations

Evidence for a correlation between nitric oxide formation by cleavage of organic nitrates and activation of guanylate cyclase

1985 • 52 citations

Preservation of endothelial cell structure and function by intracoronary perfluorochemical in a canine preparation of reperfusion.

1987 • 49 citations

Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats.

1990 • 49 citations

Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A

1989 • 48 citations

Severe neutrophil depletion by leucocyte filters or cytotoxic drug does not improve recovery of contractile function in stunned porcine myocardium

1993 • 46 citations

Effects of Perfusion and Endothelium on the Reactivity of Isolated Resistance Arteries

1985 • 45 citations

Neutrophils and mononuclear cells from patients with chronic granulomatous disease release nitric oxide.

1993 • 42 citations

Polymorphonuclear leukocytes induced vasoconstriction in isolated canine coronary arteries.

1990 • 42 citations

CDw18 Dependent Adhesion of Leukocytes to Endothelium and Its Relevance for Cardiac Reperfusion

1990 • 40 citations

Neutrophil mediated myocardial injury

1993 • 36 citations

Changes of tracheal smooth muscle stiffness during an isotonic contraction

1989 • 36 citations

Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP.

1990 • 35 citations

Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro

1990 • 34 citations

Postischemic dysfunction of the heart induced by small numbers of neutrophils via formation of hypochlorous acid

1993 • 32 citations

Coronary blood flow in rats is dependent on the release of vascular nitric oxide.

1992 • 29 citations

Modulation of vascular tone by neutrophils: dependence on endothelial integrity

1989 • 28 citations

Impaired vasodilatation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs

1990 • 27 citations

Vascular responses to activated leukocytes after regression of atherosclerosis.

1992 • 22 citations

Mechanisms of Vasodilatation

1986 • 22 citations

Analysis and Simulation of the Cardiac System — Ischemia

2020 • 16 citations

The influence of isosorbide dinitrate and molsidomine on migration of polymorphonuclear neutrophils in vivo

1990 • 5 citations

The sarcolemma in low-flow and total ischemia of canine left ventricle

1986 • 5 citations

Nitric oxide donor SIN-1 inhibits neutrophil activation both directly and via platelet-mediated mechanism

1992 • 4 citations

SIN-1, an active metabolite of molsidomine alters neutrophil functions

1990 • 1 citations

Deleted Work

1955 • 0 citations