Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Septic Shock in Humans

1990 • 1,170 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

1985 • 620 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo.

1991 • 499 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

1990 • 399 citations

Electrical properties of individual cells isolated from adult rat ventricular myocardium.

1980 • 394 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor.

1986 • 381 citations

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

1986 • 338 citations

Development of myocardial dysfunction in endotoxin shock

1985 • 297 citations

Regional and cardiac haemodynamic effects of N^G‐nitro‐<scp>l</scp>‐arginine methyl ester in conscious, Long Evans rats

1990 • 268 citations

Identification of N‐iminoethyl‐<scp>l</scp>‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

1991 • 258 citations

Factors released from endocardium of the ferret and pig modulate myocardial contraction.

1991 • 242 citations

The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids

1992 • 233 citations

Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.

1983 • 211 citations

Nitric oxide synthase in cultured endocardial cells of the pig

1991 • 164 citations

Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart.

1973 • 155 citations

Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

1991 • 146 citations

Stoichiometry of the reaction of oxyhemoglobin with nitrite

1979 • 141 citations

Origin of myocardial depressant factor in shock

1970 • 129 citations

Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma

1989 • 125 citations

Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?

1977 • 123 citations

Interleukin-1-induced myocardial depression in an isolated beating heart preparation.

1989 • 102 citations

Effects of 8-Bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle

1991 • 101 citations

Myocardial Dysfunction in Sepsis

1989 • 84 citations

Myocardial Toxic Effects During Recombinant Interleukin-2 Therapy

1989 • 80 citations

Effects of E. coli endotoxemia on ventricular performance

1966 • 72 citations

Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide‐dependent and inhibited by dexamethasone

1991 • 66 citations

Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondria

1989 • 66 citations

Effects of interleukin 2 on cardiac function in the isolated rat heart.

1990 • 63 citations

Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells

1991 • 58 citations

Basal and stimulated formation and release of L-arginine-derived nitrogen oxides from cultured endothelial cells.

1990 • 57 citations

Distribution and metabolism of ingested NO3- and NO2- in germfree and conventional-flora rats

1979 • 47 citations

Injection of guanosine 5'-cyclic monophosphate into heart cells blocks calcium slow channels

1985 • 47 citations

Circulatory effects of hydrocortisone and protection against endotoxin shock in cats

1970 • 45 citations

Influence of corticosteroids on mechanical performance of isolated rat papillary muscles

1968 • 45 citations

A cardiodepressant factor isolated from blood blocks Ca2+ current in cardiomyocytes

1991 • 38 citations

Mechanism of cardiac dysfunction in hearts from endotoxin-treated rats.

1986 • 35 citations

Left ventricular performance in endotoxin shock in dogs

1982 • 29 citations

Yohimbine increases submaxillary kallikrein release into the saliva in dogs: evidence for α₂‐adrenoceptor‐mediated inhibition of cholinergic pathways

1991 • 19 citations

Does the heart fail in endotoxin shock?

1990 • 15 citations

DEPRESSION OF ISOLATED HEART MUSCLE BY BACTERIAL ENDOTOXIN

1973 • 11 citations

IL-1 inhibits β-adrenergic respcnsiveness in intact human ventricular myocardium

1991 • 8 citations

Decreases in left ventricular contractility during endotoxin shock in rabbits.

1989 • 6 citations