Signal Transducer and Activator of Transcription 3 Activation Promotes Invasive Growth of Colon Carcinomas through Matrix Metal loproteinase Induction

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

1994 • 4,818 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Regulation of matrix metalloproteinase expression in tumor invasion

1999 • 1,503 citations

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

2002 • 1,027 citations

Matrix metalloproteinases in tumor invasion and metastasis

2000 • 820 citations

What does Stat3 do?

2002 • 810 citations

Stat proteins and oncogenesis

2002 • 776 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

What does Stat3 do?

2002 • 685 citations

Matrix metalloproteinases in tumour invasion and metastasis

1999 • 670 citations

Stat proteins and oncogenesis

2002 • 660 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

2004 • 539 citations

A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.

1998 • 532 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 449 citations

Matrix Metalloproteinases in Human Melanoma

2000 • 414 citations

Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth

2005 • 397 citations

Activation of Stat3 in Human Melanoma Promotes Brain Metastasis

2006 • 378 citations

Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.

2002 • 376 citations

DNA Binding Specificity of Different STAT Proteins

2001 • 366 citations

Proceedings: Second international conference on intelligent systems for molecular biology

1994 • 349 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 312 citations

Experimental metastasis is suppressed in MMP-9-deficient mice.

1999 • 300 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

Activated Signal Transducer and Activator of Transcription (STAT) 3

2004 • 252 citations

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

2001 • 247 citations

Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.

1999 • 238 citations

Stat5 tetramer formation is associated with leukemogenesis

2005 • 232 citations

Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

2006 • 231 citations

The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor-β1

2003 • 227 citations

Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas

1999 • 225 citations

Protein Kinase C-ζ Regulates Transcription of the Matrix Metalloproteinase-9 Gene Induced by IL-1 and TNF-α in Glioma Cells via NF-κB

2002 • 193 citations

Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.

2001 • 190 citations

Stat3 Controls Cell Movements during Zebrafish Gastrulation

2002 • 177 citations

The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression

1997 • 172 citations

The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

2001 • 169 citations

Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma: A Study of Incidence and Its Association With Pathological Features and Clinical Outcome

2002 • 164 citations

Matrix Metalloproteinase Gene Expression^a

1994 • 156 citations

A Role of STAT3 in Rho GTPase-regulated Cell Migration and Proliferation

2005 • 140 citations

High expression levels of collagenase‐1 and stromelysin‐1 correlate with shorter disease‐free survival in human metastatic melanoma

2001 • 136 citations

Inhibition of Growth and Metastasis of Human Hepatocellular Carcinoma by Antisense Oligonucleotide Targeting Signal Transducer and Activator of Transcription 3

2006 • 131 citations

The p38 SAPK Pathway Regulates the Expression of the MMP-9 Collagenase via AP-1-Dependent Promoter Activation

2001 • 119 citations

STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the α2-macroglobulin gene

2003 • 115 citations

Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.

2001 • 112 citations

Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.

1999 • 107 citations

Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase.

1992 • 106 citations

Trophoblast invasion: tuning through LIF, signalling via Stat3

2005 • 104 citations

Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells

2005 • 100 citations

Overexpression of Phosphorylated-STAT3 Correlated with the Invasion and Metastasis of Cutaneous Squamous Cell Carcinoma

2005 • 97 citations

Expression of Matrix Metalloproteinase-1 in Human Colorectal Carcinoma

2000 • 92 citations

Synergistic induction of matrix metalloproteinase 1 by interleukin-1? and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism

2001 • 83 citations

Homodimerization of Interleukin-4 Receptor α Chain Can Induce Intracellular Signaling

1996 • 75 citations

Hydrogen peroxide promotes transformation of rat liver non‐neoplastic epithelial cells through activation of epidermal growth factor receptor

2001 • 75 citations

Prognostic Significance of MMP-1 and MMP-3 Functional Promoter Polymorphisms in Colorectal Cancer

2005 • 68 citations

Differential Expression and Activity Status of MMP-1, MMP-2 and MMP-9 in Tumor and Stromal Cells of Squamous Cell Carcinomas of the Lung

2002 • 67 citations

Oncostatin M Differentially Regulates Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-3 Gene Expression in Human Synovial Lining Cells

1996 • 62 citations

Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers

2002 • 59 citations

Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

2004 • 54 citations

Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats

1999 • 51 citations

Fibroblast Growth Factor-1 Induced Promatrilysin Expression Through the Activation of Extracellular-regulated Kinases and STAT3

2002 • 48 citations

Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes

2004 • 44 citations

STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells

2002 • 41 citations

v-src activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: Requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors

1998 • 34 citations

Low Collagenase-1 (MMP-1) and MT1-MMP Expression Levels Are Favourable Survival Markers in Advanced Colorectal Carcinoma

2003 • 32 citations

CD40L Induces Matrix-Metalloproteinase-9 but Not Tissue Inhibitor of Metalloproteinases-1 in Cervical Carcinoma Cells: Imbalance between NF-κB and STAT3 Activation

2001 • 31 citations

Activation of the c‐Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3

2005 • 30 citations

Glycine‐extended gastrin induces matrix metalloproteinase‐1‐ and ‐3‐mediated invasion of human colon cancer cells through type I collagen gel and Matrigel

2004 • 22 citations

Ets Domain Transcription Factor PE1 Suppresses Human Interstitial Collagenase Promoter Activity by Antagonizing Protein−DNA Interactions at a Critical AP1 Element

2000 • 20 citations