Protein Kinase C-ζ Regulates Transcription of the Matrix Metalloproteinase-9 Gene Induced by IL-1 and TNF-α in Glioma Cells via NF-κB

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

2001 • 395 citations

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

1997 • 290 citations

Bicistronic Vector for the Creation of Stable Mammalian Cell Lines that Predisposes All Antibiotic-Resistant Cells to Express Recombinant Protein

1996 • 288 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors.

1993 • 260 citations

Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window

1995 • 260 citations

Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells

1996 • 253 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

Ceramide Directly Activates Protein Kinase C ζ to Regulate a Stress-activated Protein Kinase Signaling Complex

2000 • 226 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways

2000 • 207 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion.

2000 • 162 citations

Sphingomyelinase and Ceramide Stimulate the Expression of Inducible Nitric-oxide Synthase in Rat Primary Astrocytes

1998 • 162 citations

PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor

1999 • 142 citations

Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.

1994 • 124 citations

Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity

1993 • 123 citations

Nucleolin Is a Protein Kinase C-ζ Substrate

1997 • 120 citations

Inhibition of Phosphatidylinositol 3-Kinase Induces Nitric-oxide Synthase in Lipopolysaccharide- or Cytokine-stimulated C6 Glial Cells

1999 • 120 citations

Fibronectin-mediated Cell Adhesion Is Required for Induction of 92-kDa Type IV Collagenase/Gelatinase (MMP-9) Gene Expression during Macrophage Differentiation

1998 • 119 citations

Protein Kinase C-α Modulates Lipopolysaccharide-induced Functions in a Murine Macrophage Cell Line

1998 • 108 citations

Dual Role of Pseudosubstrate in the Coordinated Regulation of Protein Kinase C by Phosphorylation and Diacylglycerol

2000 • 100 citations

Expression of a Dominant‐Negative Mutant of p21^ras Inhibits Induction of Nitric Oxide Synthase and Activation of Nuclear Factor‐κB in Primary Astrocytes

2000 • 90 citations

Induction of Matrix Metalloproteinase-9 Requires a Polymerized Actin Cytoskeleton in Human Malignant Glioma Cells

1998 • 76 citations

HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway

2001 • 75 citations

In vitro expression of MMP-2 and MMP-9 in glioma cells following exposure to inflammatory mediators

1998 • 68 citations

Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation.

1994 • 60 citations

The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-ζ

1992 • 54 citations

Interleukin 1-β-induced protein kinase C-ζ activation is mimicked by exogenous phospholipase D

1997 • 47 citations

Induction of fibroblast gelatinase B expression by direct contact with cell lines derived from primary tumor but not from metastases.

1996 • 46 citations

The Metastatic Characteristics of Murine Lymphoma Cell Lines In Vivo Are Manifested After Target Organ Invasion

1998 • 31 citations

Sequence and expression of human protein kinase C-ϵ

1992 • 28 citations