What does Stat3 do?

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1998 • 1,518 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

2000 • 1,150 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

1999 • 885 citations

Serine phosphorylation of STATs

2000 • 873 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Stat proteins and oncogenesis

2002 • 776 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Stat proteins and oncogenesis

2002 • 660 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1998 • 513 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Essential role of STAT3 for embryonic stem cell pluripotency

1999 • 404 citations

Interleukin-10 Receptor Signaling through the JAK-STAT Pathway

1999 • 384 citations

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

2001 • 331 citations

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1994 • 317 citations

STAT family of transcription factors in cytokine-mediated biological responses

2000 • 311 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

Leukemia Inhibitory Factor–dependent Transcriptional Activation in Embryonic Stem Cells

1997 • 217 citations

STAT-3 Activation Is Required for Normal G-CSF-Dependent Proliferation and Granulocytic Differentiation

2001 • 202 citations

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult

2002 • 184 citations

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

1994 • 162 citations

gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways

1996 • 147 citations

Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons

2001 • 146 citations

Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

2002 • 137 citations

Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons

2001 • 136 citations

Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival

2001 • 109 citations

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

2000 • 109 citations

STAT signaling is active during early mammalian development

1997 • 99 citations

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3- deficient T lymphocytes

1998 • 92 citations

Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?

1990 • 90 citations

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

1997 • 68 citations