Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

The ARF/p53 pathway

2000 • 647 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives

1975 • 340 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Survivin apoptosis: an interloper between cell death and cell proliferation in cancer.

1999 • 284 citations

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

1999 • 196 citations

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

1999 • 159 citations

Epidermal growth factor-induced growth inhibition requires Stat1 activation.

1998 • 100 citations

Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli

1999 • 91 citations

Regulation of both apoptosis and cell survival by the v-Src oncoprotein

2000 • 74 citations

Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras.

1998 • 66 citations

Insulin/IGF-I Rescues Immortalized Brown Adipocytes from Apoptosis Down-Regulating Bcl-xS Expression, in a PI 3-Kinase- and Map Kinase-Dependent Manner

1998 • 60 citations

Loss of STAT1 expression confers resistance to IFN‐γ‐induced apoptosis in ME180 cells

1999 • 47 citations

The molecular basis of carcinogenesis: understanding the cell cycle clock.

1996 • 42 citations