Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3 as an Oncogene

1999 • 2,770 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Cytokine receptor signalling

1995 • 1,242 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

2000 • 1,150 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Serine phosphorylation of STATs

2000 • 873 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

The Stat family in cytokine signaling

2001 • 723 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

STAT proteins: novel molecular targets for cancer drug discovery

2000 • 634 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

Mechanism-Based Target Identification and Drug Discovery in Cancer Research

2000 • 607 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

2001 • 436 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

1998 • 426 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

1999 • 375 citations

STAT signaling in head and neck cancer

2000 • 374 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

2000 • 363 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

1997 • 336 citations

Complex roles of Stat1 in regulating gene expression

2000 • 326 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

2000 • 314 citations

The biology of Stat4 and Stat6

2000 • 310 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

2000 • 295 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

The role of STAT proteins in growth hormone signaling

2000 • 280 citations

Negative regulation of cytokine signaling

2001 • 259 citations

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

1999 • 259 citations

Bcr/Abl activates transcription of theBcl-X gene through STAT5

2000 • 249 citations

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

1999 • 247 citations

STAT signaling in the pathogenesis and treatment of leukemias

2000 • 242 citations

STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells

2000 • 235 citations

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5

2000 • 234 citations

The role of STATs in myeloid differentiation and leukemia

2000 • 230 citations

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

2000 • 225 citations

Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents

1999 • 217 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

1999 • 207 citations

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

1998 • 206 citations

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

2000 • 201 citations

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

1995 • 195 citations

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

1999 • 191 citations

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils

2001 • 180 citations

STAT proteins as novel targets for cancer therapy

1999 • 180 citations

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

2001 • 175 citations

Studies of IFN-Induced Transcriptional Activation Uncover the Jak-Stat Pathway

1998 • 173 citations

Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells

1999 • 171 citations

The roles of the Drosophila JAK/STAT pathway

2000 • 164 citations

Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression

1999 • 152 citations

JAK-STAT signaling activated by Abl oncogenes

2000 • 144 citations

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

1986 • 138 citations

Control of myeloid differentiation and survival by Stats

2000 • 136 citations

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

2001 • 127 citations

Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

1997 • 121 citations

Distinct roles of the NH ₂ - and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1–Stat1 interaction

2000 • 119 citations

Stat5 and Sp1 Regulate Transcription of the Cyclin D2 Gene in Response to IL-2

2001 • 112 citations

Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins

1999 • 111 citations

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

2000 • 109 citations

Abrogation of Interleukin-3 Dependence of Myeloid Cells by the v-src Oncogene Requires SH2 and SH3 Domains Which Specify Activation of STATs

1997 • 108 citations

Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines.

1996 • 99 citations

The role of STATs in proliferation, differentiation, and apoptosis

1999 • 99 citations

Pharmaceutical intervention in the JAK/STAT signaling pathway

2000 • 95 citations

Androgen-receptor-interacting nuclear proteins

2000 • 85 citations

Activation of Estrogen Receptor Blocks Interleukin-6-inducible Cell Growth of Human Multiple Myeloma Involving Molecular Cross-talk between Estrogen Receptor and STAT3 Mediated by Co-regulator PIAS3

2001 • 80 citations

Physiological significance of STAT proteins: investigations through gene disruption in vivo

1999 • 79 citations

JAKs and STATs in invertebrate model organisms

1999 • 66 citations

STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells.

2000 • 63 citations

Interferons as a paradigm for cytokine signal transduction

1999 • 50 citations

Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor β-chain in BCR-ABL+human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition

2001 • 48 citations

Localization of a Target Region of Allelic Loss to a 1‐cM Interval on Chromosome 16p.13.13 in Hepatocellular Carcinoma

1999 • 21 citations