Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

AJCC Cancer Staging Manual

2002 • 6,356 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

The classification of cancer of the rectum

1932 • 1,529 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

2004 • 539 citations

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

2003 • 502 citations

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

2002 • 421 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.

2002 • 376 citations

STAT signaling in head and neck cancer

2000 • 374 citations

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells

2004 • 297 citations

Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer

2003 • 244 citations

Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.

1994 • 242 citations

Invasion of veins by carcinoma of rectum: method of detection, histological features and significance

1981 • 224 citations

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.

2003 • 194 citations

Constitutive Activation of Stat 3 Oncogene Product in Human Ovarian Carcinoma Cells

2000 • 188 citations

Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors

2005 • 171 citations

Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma: A Study of Incidence and Its Association With Pathological Features and Clinical Outcome

2002 • 164 citations

Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma

2001 • 151 citations

Increasing colorectal cancer incidence rates in Japan

2004 • 140 citations

Expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Expression of Vascular Endothelial Growth Factor in and Angiogenic Phenotype of Human Gastric Cancer

2005 • 140 citations

The prognosis after surgical treatment for carcinoma of the rectum

1976 • 135 citations

Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma

2004 • 113 citations

Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis

2003 • 100 citations

Importance of tumor pathology and morphology in patients with surgically resected colon cancer. Findings from the gastrointestinal tumor study group

1986 • 86 citations

Stat3 and G-CSF-Induced Myeloid Differentiation

1998 • 84 citations

Stat proteins and oncogenesis

2002 • 82 citations

Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils

1998 • 63 citations

The surgical pathology of rectal cancer

1950 • 19 citations