Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

Overview of matrix metalloproteinase expression in cultured human cells

1998 • 259 citations

Expression and localization of matrix‐degrading metalloproteinases during colorectal tumorigenesis

1994 • 256 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

1996 • 195 citations

Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumours

1991 • 192 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.

1995 • 184 citations

Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors

1983 • 176 citations

Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas

1995 • 145 citations

Cancer Invasion and Metastases

1990 • 136 citations

Matrix metalloproteinase inhibitors: Present achievements and future prospects

1997 • 128 citations

Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer

1996 • 125 citations

Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human colorectal cancer and liver metastases

1995 • 106 citations

Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma.

1996 • 104 citations

Apical Enrichment of Human EGF Precursor in Madin-Darby Canine Kidney Cells Involves Preferential Basolateral Ectodomain Cleavage Sensitive to a Metalloprotease Inhibitor

1997 • 90 citations

The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.

1996 • 88 citations

Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed byin situ hybridization and immunoelectron microscopy

1996 • 83 citations

Comparisons of colon–cancer survival among european countries: The eurocare study

1995 • 71 citations

Matrix Metalloproteinase Inhibition Attenuates Human Pancreatic Cancer Growthin Vitroand Decreases Mortality and Tumorigenesisin Vivo

1997 • 66 citations

Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model

1996 • 60 citations

Matrilysin gene expression in sporadic and familial colorectal adenomas

1997 • 41 citations

Regression induced by lentinan, of peritoneal carcinomatoses in a model of colon cancer in rat

1988 • 18 citations

Octreotide (SMS 201–995) inhibits the growth of colon peritoneal carcinomatosis in BDIX rats

1993 • 14 citations

IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT

1995 • 2 citations