Prerequisites for the Antitumor Vaccine-Like Effect of Chemotherapy and Radiotherapy

Dendritic cells and the control of immunity

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

Mitochondrial Membrane Permeabilization in Cell Death

2007 • 3,375 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

2008 • 3,166 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Modes of resistance to anti-angiogenic therapy

2008 • 2,783 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

Molecular mechanisms of necroptosis: an ordered cellular explosion

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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

2000 • 2,023 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

2009 • 1,694 citations

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

2009 • 1,684 citations

Immunological aspects of cancer chemotherapy

2007 • 1,535 citations

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

2009 • 1,517 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

2009 • 1,449 citations

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

2009 • 1,405 citations

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

2000 • 1,385 citations

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

2005 • 1,331 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

2005 • 1,246 citations

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2006 • 1,180 citations

Immunogenic death of colon cancer cells treated with oxaliplatin

2009 • 1,041 citations

Pathways of apoptotic and non-apoptotic death in tumour cells

2004 • 1,026 citations

Immune infiltration in human tumors: a prognostic factor that should not be ignored

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Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

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Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Systemic effects of local radiotherapy

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Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Mitotic catastrophe: a mechanism for avoiding genomic instability

2011 • 747 citations

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

2009 • 743 citations

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

2010 • 682 citations

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

2009 • 679 citations

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

2008 • 650 citations

The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo

2002 • 641 citations

The anticancer immune response: indispensable for therapeutic success?

2008 • 556 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

2007 • 531 citations

Decoding Cell Death Signals in Inflammation and Immunity

2010 • 519 citations

The extracellular release of HMGB1 during apoptotic cell death

2006 • 509 citations

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

2008 • 492 citations

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

2010 • 467 citations

Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ

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The inflammasomes: mechanisms of activation and function

2010 • 443 citations

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

2010 • 438 citations

Oncogenic stress sensed by the immune system: role of natural killer cell receptors

2009 • 384 citations

Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

2005 • 373 citations

Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

2007 • 367 citations

Man the barrier! strategic defences in the intestinal mucosa

2001 • 362 citations

Natural Killer Cell–Mediated Lysis of Hepatoma Cells via Specific Induction of NKG2D Ligands by the Histone Deacetylase Inhibitor Sodium Valproate

2005 • 351 citations

Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis

2007 • 343 citations

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

2010 • 324 citations

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

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Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

1995 • 313 citations

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

2011 • 310 citations

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

2011 • 305 citations

Immunogenic cancer cell death: a key-lock paradigm

2008 • 294 citations

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell–dependent antitumor effects

2004 • 285 citations

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

2011 • 278 citations

Targeted cytoplasmic irradiation induces bystander responses

2004 • 267 citations

Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer

2000 • 196 citations

Chemotherapy and radiotherapy: Cryptic anticancer vaccines

2010 • 189 citations

Ecto‐calreticulin in immunogenic chemotherapy

2007 • 187 citations

Recent Developments in Cancer Vaccines

2011 • 184 citations

Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients

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Importance of cyclophosphamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice.

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Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients

2010 • 159 citations

Autologous Dendritic Cell Vaccines for Non–Small-Cell Lung Cancer

2004 • 157 citations

Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

2010 • 153 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

2005 • 148 citations

Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1β Release from Human Monocytes

2004 • 144 citations

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

2008 • 140 citations

SREC-I, a Type F Scavenger Receptor, Is an Endocytic Receptor for Calreticulin

2004 • 138 citations

Immunotherapy: Bewitched, Bothered, and Bewildered No More

2004 • 136 citations

Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs

2010 • 118 citations

Defining the Ability of Cyclophosphamide Preconditioning to Enhance the Antigen-specific CD8+ T-cell Response to Peptide Vaccination: Creation of a Beneficial Host Microenvironment Involving Type I IFNs and Myeloid Cells

2006 • 115 citations

Surface‐exposed calreticulin in the interaction between dying cells and phagocytes

2010 • 107 citations

Successful combination of local CpG‐ODN and radiotherapy in malignant glioma

2005 • 104 citations

Targeting p53 to mitochondria for cancer therapy

2008 • 103 citations

Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy

2011 • 92 citations

Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4 ⁺ T lymphocytes

2004 • 88 citations

How to improve the immunogenicity of chemotherapy and radiotherapy

2011 • 83 citations

Cyclophosphamide Induces Dynamic Alterations in the Host Microenvironments Resulting in a Flt3 Ligand-Dependent Expansion of Dendritic Cells

2010 • 64 citations

Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

2011 • 61 citations

Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo

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Disruption of the PP1/GADD34 complex induces calreticulin exposure

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Host restriction of Friend Leukemia Virus; fate of input virion RNA

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Current Experience With CTLA4-blocking Monoclonal Antibodies for the Treatment of Solid Tumors

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DNA binding by N- and L-Myc proteins.

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DNA repair pathways and their implication in cancer treatment

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Interaction of Calreticulin with CD40 Ligand, TRAIL and Fas Ligand

2007 • 25 citations

Monoclonal antibodies for medical oncology: a few critical perspectives

2011 • 5 citations

Quimioterapia de combinación cisplatino y vinorelbina en carcinoma no microcítico pulmonar (NSCLC) inoperable: un ensayo fase II multicéntrico

2000 • 1 citations

What's in a face?

2006 • 1 citations