Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Fibroblasts in cancer

2006 • 4,177 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Epithelial-mesenchymal transition and its implications for fibrosis

2003 • 2,239 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Epithelial-mesenchymal transition and its implications for fibrosis

2003 • 2,110 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

2006 • 1,020 citations

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

2006 • 970 citations

EMT: When epithelial cells decide to become mesenchymal-like cells

2009 • 905 citations

Tissue repair and the dynamics of the extracellular matrix

2004 • 885 citations

Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type

2006 • 782 citations

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

2009 • 579 citations

The tumor microenvironment and its contribution to tumor evolution toward metastasis

2008 • 501 citations

WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors

1998 • 499 citations

Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis

2002 • 487 citations

Matrix metalloproteinases in tumor–host cell communication

2002 • 376 citations

Trafficking and differentiation of mesenchymal stem cells

2009 • 366 citations

Malignant transformation in a nontumorigenic human prostatic epithelial cell line.

2001 • 343 citations

Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

1988 • 319 citations

Activation of Notch1 signaling is required for -catenin-mediated human primary melanoma progression

2005 • 306 citations

Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis

2001 • 298 citations

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

2007 • 287 citations

Notch signaling regulates tumor angiogenesis by diverse mechanisms

2008 • 269 citations

Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression

2006 • 263 citations

Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI

2008 • 254 citations

Human Melanoma Progression in Skin Reconstructs

2000 • 217 citations

The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway

2002 • 195 citations

Notch signaling: Emerging molecular targets for cancer therapy

2010 • 169 citations

Expression of Cyr61, CTGF, and WISP-1 Correlates with Clinical Features of Lung Cancer

2007 • 129 citations

Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes

2009 • 110 citations

Overexpression of WISP-1 Down-regulated Motility and Invasion of Lung Cancer Cells through Inhibition of Rac Activation

2003 • 107 citations

Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis

2008 • 98 citations

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma

2001 • 82 citations

Differential Expression and Prognostic Implications of the CCN Family Members WISP-1, WISP-2, and WISP-3 in Human Breast Cancer

2007 • 79 citations

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

2008 • 51 citations

Targeting the Tumor Stroma in Cancer Therapy

2009 • 48 citations

Identification of E-selectin as a Novel Target for the Regulation of Postnatal Neovascularization

2010 • 46 citations

Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct Phenotypes

2008 • 31 citations

Molecular biology of cutaneous melanoma

2003 • 24 citations

Molecular biology of cutaneous melanoma

2015 • 5 citations