Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell–dependent antitumor effects

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

2002 • 3,274 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

2003 • 2,216 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

2001 • 964 citations

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

2003 • 820 citations

Natural killer cells and dendritic cells: rendezvous in abused tissues

2002 • 674 citations

Response to Imatinib Mesylate in Patients with Chronic Myeloproliferative Diseases with Rearrangements of the Platelet-Derived Growth Factor Receptor Beta

2002 • 642 citations

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

1990 • 599 citations

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumorin vivo

2001 • 588 citations

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

2002 • 582 citations

Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia.

2002 • 459 citations

Functional interactions between dendritic cells and NK cells during viral infection

2002 • 362 citations

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

2002 • 331 citations

Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity

2002 • 277 citations

Pharmacology of imatinib (STI571)

2002 • 261 citations

Adverse cutaneous reactions to imatinib (STI571) in Philadelphia chromosome-positive leukemias: A prospective study of 54 patients

2003 • 230 citations

Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity.

1987 • 181 citations

Macrophage-derived chemokine (MDC)

2000 • 178 citations

Natural Killer and Dendritic Cell Contact in Lesional Atopic Dermatitis Skin –Malassezia-Influenced Cell Interaction

2002 • 158 citations

Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype

2000 • 146 citations

Clonal nature of mast-cell clusters formed in W/Wv mice after bone marrow transplantation

1979 • 91 citations

The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells

2000 • 87 citations

Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL–expressing cells, demonstrating synergy between AG490 and STI571

2001 • 79 citations

Dendritic cells (DC) promote natural killer (NK) cell functions: dynamics of the human DC/NK cell cross talk.

2002 • 78 citations

A renaissance for the tumor immunosurveillance hypothesis

2001 • 78 citations

Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT

2003 • 73 citations

Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729.

2018 • 70 citations

Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells.

1994 • 45 citations