Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Androgen Receptor in Prostate Cancer

2004 • 1,679 citations

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

1996 • 393 citations

Androgen Receptor Mutations in Androgen-Independent Prostate Cancer: Cancer and Leukemia Group B Study 9663

2003 • 362 citations

Beneficial health effects of lupeol triterpene: A review of preclinical studies

2010 • 319 citations

Androgen receptor mutations in prostate cancer.

1996 • 301 citations

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

2011 • 255 citations

Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer

2007 • 241 citations

Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination

2009 • 222 citations

Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression

2011 • 201 citations

Coregulator Recruitment and Histone Modifications in Transcriptional Regulation by the Androgen Receptor

2004 • 190 citations

Collocation of androgen receptor gene mutations in prostate cancer.

2001 • 180 citations

New Strategies in Metastatic Prostate Cancer: Targeting the Androgen Receptor Signaling Pathway

2011 • 177 citations

Mechanism of Antiandrogen Action: Key Role of Hsp90 in Conformational Change and Transcriptional Activity of the Androgen Receptor

2002 • 167 citations

β-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription

2003 • 162 citations

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor–p160 coactivator complex

2003 • 154 citations

Bone metastatic LNCaP‐derivative C4‐2B prostate cancer cell line mineralizes in vitro

2001 • 154 citations

Androgen receptor action in hormone‐dependent and recurrent prostate cancer

2006 • 136 citations

Androgen Receptor Mutations in Prostate Cancer

1996 • 131 citations

Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway

2005 • 131 citations

A Novel Dietary Triterpene Lupeol Induces Fas-Mediated Apoptotic Death of Androgen-Sensitive Prostate Cancer Cells and Inhibits Tumor Growth in a Xenograft Model

2005 • 127 citations

Aberrant Activation of the Androgen Receptor by NF-κB2/p52 in Prostate Cancer Cells

2010 • 109 citations

CYP17 inhibition as a hormonal strategy for prostate cancer

2008 • 104 citations

Non-competitive androgen receptor inhibition in vitro and in vivo

2009 • 100 citations

Measurement of Protein–DNA Interactions In Vivo by Chromatin Immunoprecipitation

2004 • 97 citations

Suppression of cFLIP by Lupeol, a Dietary Triterpene, Is Sufficient to Overcome Resistance to TRAIL-Mediated Apoptosis in Chemoresistant Human Pancreatic Cancer Cells

2009 • 95 citations

Multifaceted interaction between the androgen and Wnt signaling pathways and the implication for prostate cancer

2006 • 95 citations

Activity of Androgen Receptor Antagonist Bicalutamide in Prostate Cancer Cells Is Independent of NCoR and SMRT Corepressors

2007 • 85 citations

Lupeol inhibits proliferation of human prostate cancer cells by targeting -catenin signaling

2009 • 85 citations

PSA and Beyond: The Past, Present, and Future of Investigative Biomarkers for Prostate Cancer

2010 • 84 citations

Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice

1999 • 77 citations

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity

2010 • 63 citations

The control of prostate-specific antigen expression and gene regulation by pharmacological agents.

2001 • 59 citations

Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells

2011 • 57 citations

Effects of WNT/β-catenin pathway activation on signaling through T-cell factor and androgen receptor in prostate cancer cell lines

2005 • 53 citations

Androgen Receptor–Dependent PSA Expression in Androgen-Independent Prostate Cancer Cells Does Not Involve Androgen Receptor Occupancy of the PSA Locus

2005 • 48 citations

Bicalutamide failure in prostate cancer treatment: Involvement of Multi Drug Resistance proteins

2008 • 43 citations

Design and Synthesis of Androgen Receptor Antagonists with Bulky Side Chains for Overcoming Antiandrogen Resistance

2009 • 38 citations

Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line

2011 • 33 citations

MRI for men undergoing active surveillance or with rising PSA and negative biopsies

2010 • 24 citations