Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Use of a Monoclonal Antibody (W6/32) in Structural Studies of HLA-A,B,C Antigens

1979 • 682 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.

1987 • 381 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Domains of laminin with growth-factor activity

1989 • 341 citations

The laminin B2 chain has a multidomain structure homologous to the B1 chain.

1987 • 307 citations

High level expression of nonfused foreign genes with Autographa californica nuclear polyhedrosis virus expression vectors

1989 • 300 citations

The integrin alpha 6 beta 4 is a laminin receptor.

1992 • 299 citations

Direct Interaction of a Ligand for the erb B2 Oncogene Product with the EGF Receptor and p185 ^{erb B2}

1990 • 279 citations

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.

1994 • 273 citations

Prognostic significance of her‐2/neu expression in breast cancer and its relationship to other prognostic factors

1991 • 262 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

1991 • 208 citations

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

1994 • 198 citations

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.

1995 • 149 citations

Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185.

1989 • 131 citations

4. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer

1990 • 130 citations

Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.

1993 • 119 citations

Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.

1989 • 114 citations

Selection of monoclonal antibodies which induce internalization and phosphorylation of P185^HER2 and growth inhibition of cells with HER2/neu gene amplification

1991 • 109 citations

Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells.

1992 • 104 citations

Ligand and p185c-neu density govern receptorinteractions and tyrosine kinase activation.

1994 • 92 citations

17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.

1993 • 89 citations

Characterization of a neu/c-erbB-2 protein-specific activating factor.

1991 • 66 citations

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1994 • 65 citations

Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression

1992 • 60 citations

The epidermal growth factor receptor and the product of the neu protooncogene are members of a receptor tyrosine phosphorylation cascade.

1990 • 52 citations

Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney.

1992 • 39 citations

p185 HER2/neu Epitope Mapping with Murine Monoclonal Antibodies

1992 • 33 citations

Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas

1995 • 32 citations

A 25 kDa polypeptide is the ligand for p185neu and is secreted by activated macrophages.

1991 • 32 citations

Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site

1991 • 27 citations

Colocalization of the p185^HER2 oncoprotein and integrin α6β4 in Calu‐3 lung carcinoma cells

1994 • 16 citations

Significance of immunohistochemical c-erbB-2 product localization pattern for prognosis of primary human breast cancer

1994 • 15 citations