The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression.

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1994 • 436 citations

Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility

1992 • 396 citations

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1995 • 363 citations

CD44H regulates tumor cell migration on hyaluronate-coated substrate.

1992 • 334 citations

Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation

1995 • 294 citations

Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity.

1994 • 231 citations

CD44 and the adhesion of neoplastic cells.

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Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM.

1995 • 203 citations

Hyaluronan and cell locomotion

1992 • 200 citations

Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

1991 • 198 citations

CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer.

1995 • 159 citations

Distribution of hyaluronan and its CD44 receptor in the epithelia of human skin appendages

1992 • 142 citations

pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM.

1996 • 140 citations

Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression.

1996 • 135 citations

Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers.

1996 • 130 citations

Are CD44 variant isoforms involved in human tumour progression?

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ras gene alterations and enhanced levels of ras p21 expression in a spectrum of benign and malignant human mammary tissues.

1986 • 104 citations

Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44

1996 • 97 citations

RHAMM, a Receptor for Hyaluronan-Mediated Motility, on Normal Human Lymphocytes, Thymocytes and Malignant B Cells: a Mediator in B cell Malignancy?

1994 • 96 citations

Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes

1993 • 90 citations

Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.

1997 • 83 citations

Differential expression of the hyaluronan receptors CD44 and RHAMM in human pancreatic cancer cells.

1996 • 79 citations

Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway

1997 • 76 citations

Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade

1997 • 70 citations

Ras-Transformed Cells Express Both CD44 and RHAMM Hyaluronan Receptors: Only RHAMM Is Essential for Hyaluronan-Promoted Locomotion

1993 • 69 citations

Characterization of the murine gene encoding the hyaluronan receptor RHAMM

1995 • 68 citations

The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains

1996 • 68 citations

Microdissection RT-PCR Analysis of Gene Expression in Pathologically Defined Frozen Tissue Sections

1996 • 64 citations

The H-ras oncogene product p21 and prognosis in human breast cancer

1991 • 59 citations

CD44 in Maligant Disorders

1996 • 54 citations

The Extracellular Matrix in Cellular Proliferation and Differentiation^a

1994 • 47 citations

CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas.

1995 • 47 citations

Functional hyaluronan receptors are expressed on a squamous cell lung carcinoma cell line but not on other lung carcinoma cell lines

1996 • 45 citations

Stimulation and regulation of tumor cell motility in invasion and metastasis

1995 • 41 citations

Automated and quantitative immunocytochemical assays of CD44v6 in breast carcinomas

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Statistical Methods for Survival Data Analysis.

1995 • 26 citations

Biological indices in the assessment of breast cancer

1995 • 25 citations

expression of the cd44 variant isoforms 6 and 4/5 in breast cancer correlation with established prognostic parameters

1996 • 20 citations

CD44 exon 6 expression as a possible early prognostic factor in primary node negative breast carcinoma

1996 • 19 citations

Oncogenes and antioncogenes in human breast carcinoma.

1992 • 14 citations

Cell motility in breast cancer

1996 • 10 citations