Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profile

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

1992 • 650 citations

A murine tumor producing a matrix of basement membrane.

1977 • 602 citations

Matrix metalloproteinase inhibitors

1997 • 509 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

1997 • 403 citations

Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

1996 • 341 citations

Expression of membrane-type matrix metalloproteinase in human gastric carcinomas

1995 • 267 citations

Involvement of PA/plasmin system in the processing of pro‐MMP‐9 and in the second step of pro‐MMP‐2 activation

1997 • 255 citations

Matrix metalloproteinase inhibition: A review of anti-tumour activity

1995 • 226 citations

The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.

1997 • 218 citations

Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins

1989 • 211 citations

Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata.

1987 • 153 citations

MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

1991 • 142 citations

Autocatalytic Processing of Recombinant Human Procathepsin L

1998 • 134 citations

VIMENTIN EXPRESSION IN CERVICAL CARCINOMAS: ASSOCIATION WITH INVASIVE AND MIGRATORY POTENTIAL

1996 • 126 citations

MT-MMP expression and localisation in human lung and breast cancers

1996 • 112 citations

A new experimental metastasis model in athymic nude mice, the human malignant melanoma lox

1988 • 101 citations

Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites

1997 • 101 citations

Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors: Piperazides of 3-Amidinophenylalanine

1997 • 98 citations

Inactivation of human cystatin C and kininogen by human cathepsin D

1991 • 95 citations

Invasion of reconstituted basement membrane matrix is not correlated to the malignant metastatic cell phenotype.

1991 • 87 citations

Immunohistochemical localization of cathepsin B in neoplastic human prostate

1995 • 84 citations

Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

1993 • 77 citations

Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s)

1992 • 77 citations

Effects of Transforming Growth Factor-beta on Human Pulmonary Adenocarcinoma Cell Adhesion, Motility, and Invasion In Vitro

1992 • 73 citations

In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin

1998 • 65 citations

Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon

1992 • 62 citations

Identification of the 72-kDa (MMP-2) and 92-kDa (MMP-9) gelatinase/type IV collagenase in preparations of laminin and Matrigel.

1993 • 56 citations

Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes

1988 • 55 citations

Expression of E-cadherin, alpha, beta and gamma-catenin in human colorectal cancer.

1997 • 53 citations

Markers and characteristics of human SCLC cell lines

1987 • 52 citations

Intracellular transport and processing of lysosomal cathepsin B

1987 • 44 citations

Proteolytic enzymes : aspartic and metallo peptidases

1995 • 43 citations

Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?

1993 • 41 citations

The processing of a cathepsin L precursor in vitro

1989 • 33 citations

Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors.

1994 • 27 citations

Protease inhibitors: novel therapeutic application and development

1996 • 21 citations

Characterization of cysteine proteases and their endogenous inhibitors in MCF-7 and adriamycin-resistant MCF-7 human breast cancer cells.

1993 • 19 citations

Proteolytic enzymes at various stages of oncogenic transformation of rat fibroblasts. I. Aspartyl and cysteine proteinases

1995 • 14 citations

In Vitro Migration Capacity of Epidermal Langerhans Cells

1995 • 7 citations

The Role of Proteases in Tumor Invasion and Metastasis: Prognostic Impact and Therapeutical Challenge?

1994 • 7 citations

Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.

1985 • 1 citations