Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.

1992 • 669 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Adhesive recognition sequences

1991 • 571 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.

1991 • 447 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins.

1990 • 391 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

1992 • 358 citations

Lymphocyte interactions with extracellular matrix

1991 • 336 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

1992 • 285 citations

Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]

1991 • 281 citations

An interaction between zyxin and alpha-actinin.

1992 • 251 citations

Degradation of Fibronectin and Vitronectin and Vitronectin in Chronic Wound Fluid: Analysis by Cell Blotting, Immunoblotting, and Cell Adhesion Assays

1992 • 250 citations

Transmembrane molecular assemblies in cell-extracellular matrix interactions

1991 • 244 citations

Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules.

1990 • 243 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

1992 • 239 citations

Genetic analysis of proteoglycan structure, function and metabolism

1991 • 230 citations

In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin .alpha. subunits

1991 • 225 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Identification of the fibronectin sequences required for assembly of a fibrillar matrix.

1991 • 213 citations

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.

1992 • 208 citations

Relationship between neuronal migration and cell-substratum adhesion: laminin and merosin promote olfactory neuronal migration but are anti-adhesive.

1991 • 204 citations

Cell-surface regulation of β1-integrin activity on developing retinal neurons

1991 • 191 citations

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

1991 • 189 citations

A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.

1992 • 187 citations

Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes.

1991 • 175 citations

Anti-adhesive molecules of the extracellular matrix

1991 • 166 citations

Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin.

1991 • 165 citations

Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

1992 • 163 citations

Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin.

1992 • 162 citations

Tenascin variants: differential binding to fibronectin and distinct distribution in cell cultures and tissues.

1991 • 160 citations

Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.

1991 • 154 citations

Post-Transcriptional Steps in the Expression of Chloroplast Genes

1992 • 152 citations

Binding of two growth factor families to separate domains of the proteoglycan betaglycan.

1992 • 147 citations

Origins of human cancer: A comprehensive review

1992 • 139 citations

Regulation of integrin-type cell adhesion receptors by cytokines.

1991 • 134 citations

G1/S control of anchorage-independent growth in the fibroblast cell cycle.

1991 • 120 citations

Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts.

1992 • 109 citations

Interaction of the small proteoglycan decorin with fibronectin. Involvement of the sequence NKISK of the core protein

1991 • 108 citations

Laminin Receptors

1991 • 101 citations

Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.

1990 • 98 citations

Cloning and characterization of a gene that regulates cell adhesion

1992 • 96 citations

Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3‘,4‘-bisphosphate.

1991 • 91 citations

Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide

1992 • 86 citations

Integrins as Receptors for Extracellular Matrix

1991 • 84 citations

Spreading of HeLa cells on a collagen substratum requires a second messenger formed by the lipoxygenase metabolism of arachidonic acid released by collagen receptor clustering.

1992 • 71 citations

Stromelysin generates a fibronectin fragment that inhibits Schwann cell proliferation.

1992 • 63 citations

Cytotactin binding: inhibition of stimulated proliferation and intracellular alkalinization in fibroblasts.

1991 • 54 citations

Cell biology of extracellular matrix, 2nd edn

1992 • 50 citations

α5 Integrin Is a Critical Component of Adhesion Plaques in Myogenesis

1993 • 48 citations

Cell surface molecules that bind fibronectin's matrix assembly domain

1991 • 46 citations

The Int-2/Fgf-3 Oncogene Product Is Secreted and Associates with Extracellular Matrix: Implications for Cell Transformation

1991 • 31 citations

GTP-binding proteins and platelet activation.

1991 • 28 citations

Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells

1991 • 28 citations

Coordinate interactions of protein tyrosine kinases and protein tyrosine phosphatases in T-cell receptor-mediated signalling

1991 • 23 citations

Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling?

1992 • 22 citations

The Int-2/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation.

1991 • 20 citations

A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts.

1992 • 18 citations

GTP-binding proteins and platelet activation.

1991 • 14 citations