Toll-Like Receptor Ligands Directly Promote Activated CD4+ T Cell Survival

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Toll-like Receptor Signaling

2003 • 1,503 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

2003 • 582 citations

Toll-like receptors as adjuvant receptors

2002 • 499 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions

2002 • 489 citations

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

2001 • 445 citations

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

1972 • 431 citations

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

2002 • 406 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

Vaccinia Virus Inhibits the Maturation of Human Dendritic Cells: A Novel Mechanism of Immune Evasion

1999 • 365 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

2003 • 340 citations

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

2003 • 300 citations

Molecular mechanisms of activated T cell death in vivo

2002 • 276 citations

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

2000 • 256 citations

Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines

2002 • 241 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB

1999 • 196 citations

Role of adapters in Toll-like receptor signalling

2003 • 191 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.

1994 • 182 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

2003 • 177 citations

Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8

2001 • 170 citations

Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced byEscherichia coliInfection in Mice

2000 • 150 citations

CD28 and apoptosis

1995 • 147 citations

Subversion of the innate immune system by a retrovirus

2003 • 141 citations

Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells

1997 • 137 citations

MyD88 as a Bottle Neck in Toll/IL-1 Signaling

2002 • 136 citations

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 • 127 citations

Mitogenicity of DNA from different organisms for murine B cells.

1997 • 126 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

The role of Toll-like receptors and MyD88 in innate immune responses

2000 • 104 citations

Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs

2001 • 99 citations

T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes.

1999 • 71 citations

The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation

2001 • 68 citations

Mature dendritic cells are protected from Fas/CD95-mediated apoptosis by upregulation of Bcl-X L

2002 • 59 citations

T Cell Activation Signals Up-Regulate p38 Mitogen-Activated Protein Kinase Activity and Induce TNF-α Production in a Manner Distinct from LPS Activation of Monocytes

1999 • 53 citations

The role of Toll-like receptors and MyD88 in innate immune responses

2000 • 43 citations

Dendritic Cells and HCMV Cross-Presentation

2003 • 32 citations

Stronger Correlation of bcl‐3 than bcl‐2, bcl‐x_L, Costimulation, or Antioxidants with Adjuvant‐Induced T Cell Survival

2002 • 25 citations