The Proliferative Capacity of Individual Naive CD4+T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

The Immunological Synapse

2001 • 987 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

1999 • 390 citations

From TCR Engagement to T Cell Activation

1999 • 379 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

2001 • 219 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

T-cell signaling: The importance of receptor clustering

1997 • 155 citations

Determination of CD4 antigen density on cells: Role of antibody valency, avidity, clones, and conjugation

1998 • 151 citations

Dynamic Interactions of Macrophages with T Cells during Antigen Presentation

1999 • 146 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

2000 • 122 citations

Serial TCR Engagement and Down-Modulation by Peptide:MHC Molecule Ligands: Relationship to the Quality of Individual TCR Signaling Events

1999 • 117 citations

Antigen-induced suppression of the proliferative response of T cell clones.

1988 • 96 citations

Identification of a Role for NF-κB2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity toToxoplasma gondii

2000 • 84 citations

TCR dynamics on the surface of living T cells

2001 • 76 citations

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

1999 • 73 citations

Evidence for multivalent structure of T-cell antigen receptor complex

1995 • 72 citations

Following Antigen Challenge, T Cells Up-Regulate Cell Surface Expression of CD4 In Vitro and In Vivo

1998 • 61 citations

Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor

1996 • 54 citations

A Molecular Framework for Two-Step T Cell Signaling: Lck Src Homology 3 Mutations Discriminate Distinctly Regulated Lipid Raft Reorganization Events

2001 • 51 citations

Functional analysis of the interaction of the antigen-specific T cell receptor with its ligands.

1986 • 46 citations

A mathematical analysis of TCR serial triggering and down-regulation

2000 • 45 citations

Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naïve CD4⁺T cells

2000 • 45 citations

Expression of the T Cell Antigen Receptor ζ Chain following Activation Is Controlled at Distinct Checkpoints

1999 • 27 citations

Cooperative Activation of TCRs by Enterotoxin Superantigens

1998 • 23 citations

Selection of dual Vα T cells

1998 • 16 citations

Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells

1998 • 15 citations

Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation

2000 • 15 citations

Modulation of antigen presentation and peptide-MHC-specific, LFA-1-dependent T cell-macrophage adhesion.

1991 • 13 citations

A stable marker for specific T-cells: a TCR alpha/green fluorescent protein (GFP) fusionprotein reconstitutes a functionally active TCR complex

2000 • 10 citations

CD8+ T Lymphocytes in Double αβ TCR Transgenic Mice. II. Competitive Fitness of Dual αβ TCR CD8+ T Lymphocytes in the Peripheral Pools

2001 • 9 citations