T CELL MEMORY

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

1990 • 1,378 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

1996 • 558 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Leukocyte Migration and Adhesion

1995 • 365 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13.

1995 • 318 citations

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

1995 • 316 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

1993 • 254 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

From Naive to Memory T Cells

1996 • 252 citations

The loss of phenotypic traits by differentiated cells, V. The effect of 5-bromodeoxyuridine on cloned chondrocytes.

1968 • 245 citations

Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids.

1997 • 242 citations

Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro

1996 • 241 citations

Antigen-independent changes in naive CD4 T cells with aging.

1996 • 240 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

On the role of antigen in maintaining cytotoxic T-cell memory.

1996 • 237 citations

Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization.

1996 • 237 citations

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.

1995 • 231 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

Expression and regulation of β₇(βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system

1991 • 222 citations

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

1996 • 219 citations

Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes.

1977 • 213 citations

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.

1992 • 204 citations

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

1996 • 201 citations

Induction of long-lived germinal centers associated with persisting antigen after viral infection.

1996 • 192 citations

A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation.

1996 • 191 citations

CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.

1992 • 187 citations

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.

1994 • 182 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.

1991 • 179 citations

Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model

1997 • 176 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.

1995 • 168 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

CD8 T cell memory in B cell-deficient mice.

1996 • 158 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

Abnormal migration of T lymphocyte clones.

1982 • 153 citations

Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1).

1995 • 147 citations

Impaired primary T cell responses in L-selectin-deficient mice.

1996 • 143 citations

Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes

1997 • 137 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity.

1995 • 129 citations

Accumulation of bromodeoxyuridine‐labeled cells in central and peripheral lymphoid organs: minimal estimates of prodution and turnover rates of mature lymphocytes

1990 • 128 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

CD45RC Isoforms Define Two Types of CD4 Memory T Cells, One of which Depends on Persisting Antigen

1997 • 125 citations

Requirements for CD28-dependent T cell-mediated cytotoxicity.

1993 • 125 citations

Minimal Bystander Activation of CD8 T Cells during the Virus-induced Polyclonal T Cell Response

1997 • 118 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

Molecular mechanisms underlying functional T-cell unresponsiveness

1995 • 115 citations

The Route of Antigen Entry Determines the Requirement for L-selectin during Immune Responses

1996 • 111 citations

The Cellular Basis of Immunologic Memory

1971 • 111 citations

Lymphocyte migration into tissue: the paradigm derived from CD4 subsets

1996 • 106 citations

Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.

1996 • 101 citations

Immunity to viruses in B cell‐deficient mice: Influence of antibodies on virus persistence and on T cell memory

1996 • 100 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen.

1993 • 97 citations

Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection.

1997 • 97 citations

Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep

1996 • 90 citations

CD4⁺8⁻ help prevents rapid deletion of CD8⁺ cells after a transient response to antigen

1993 • 88 citations

Lifespan of lymphocytes

1995 • 87 citations

Cell division in the compartment of naive and memory T lymphocytes

1996 • 84 citations

Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals

1996 • 83 citations

In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice.

1995 • 81 citations

Immunosurveillance modelled in vitro: naive and memory T cells spontaneously migrate across unstimulated microvascular endothelium

1997 • 79 citations

Differential activation of CD8+ T cells by transforming growth factor-beta 1.

1993 • 77 citations

Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells

1995 • 72 citations

B‐T Lymphocyte Interactions in the Generation and Survival of Memory Cells

1996 • 68 citations

Aging and immune function: Cellular and biochemical analyses

1994 • 67 citations

Tissue-specific migration of lymphocytes: a key role for Th1 and Th2 cells ?

1996 • 66 citations

Role of antigen‐presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages

1994 • 66 citations

Fibroblasts prevent apoptosis of IL‐2‐deprived T cells without inducing proliferation: a selective effect on Bcl‐x_L expression

1996 • 64 citations

Enumeration and Characterization of Memory Cells in the TH Compartment

1996 • 51 citations

The effect of 5-bromouracil deoxyriboside on the synthesis of antibody in vitro

1960 • 48 citations

Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis.

1996 • 45 citations

Aspects of Cytotoxic T Cell Memory

1996 • 42 citations

Virgin and T cells recirculate extensively through peripheral tissues and skin during normal development of the fetal immune system

1995 • 40 citations

The monoclonal antibody MEL‐14 can block lymphocyte migration into a site ofchronic inflammation

1992 • 38 citations

Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells.

1992 • 27 citations

The effects of stress in normal and adrenalectomized mice

1985 • 24 citations

Memory TCR repertoires analyzed long-term reflect those selected during the primary response

1996 • 24 citations

Homing of lymphocytes into islets of Langerhans in prediabetic non-obese diabetic mice is not restricted to autoreactive T cells

1995 • 23 citations

The CD45RB-Associated Epitope Defined by Monoclonal Antibody CZ-1 Is an Activation and Memory Marker for Mouse CD4 T Cells

1996 • 21 citations

The Effect of Age on the Transendothelial Migration of Human T Lymphocytes

1996 • 19 citations

Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rIL-4 in vivo.

1996 • 19 citations

Transgenic/knockout mice — tools to study autoimmunity

1995 • 15 citations

L‐selectin is not essential for naive CD4 cell trafficking or development of primary responses in Peyer's patches

1997 • 10 citations