Activation of naive, memory and effector T cells

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release.

1984 • 346 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

1987 • 237 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

CD2-mediated adhesion facilitates T lymphocyte antigen recognition function

1989 • 209 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses.

1993 • 142 citations

Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen

1992 • 135 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

Requirements for CD28-dependent T cell-mediated cytotoxicity.

1993 • 125 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

T-cell memory: new perspectives

1993 • 109 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.

1989 • 96 citations

Distinct roles of IL-1 and IL-6 in human T cell activation.

1989 • 95 citations

Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.

1992 • 95 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Antigen-presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection.

1992 • 83 citations

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

1992 • 83 citations

Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway.

1992 • 78 citations

B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity.

1991 • 66 citations

Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4⁺ and CD8⁺ T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or IL-6

1992 • 65 citations

Antigen‐presenting Cells for CD8+ T Cells

1990 • 60 citations

CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0⁺ than in CD45RA⁺ human T lymphocyte subsets

1993 • 56 citations

CD28 ligation by monoclonal antibodies or B7/BB1 provides an accessory signal for the cyclosporin A-resistant generation of cytotoxic T cell activity.

1993 • 56 citations

Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy.

1993 • 52 citations

Monokine production by human T cells; IL-1 alpha production restricted to memory T cells.

1991 • 51 citations

Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation.

1990 • 48 citations

The role of macrophages in antigen presentation and T cell tolerance

1993 • 42 citations

Macrophages as accessory cells in the in vivo humoral immune response: from processing of particulate antigens to regulation by suppression.

1992 • 40 citations

Antigen presentation by B lymphocytes to CD4+ T lymphocytes in vivo: importance for B lymphocyte and T lymphocyte activation.

1992 • 31 citations

The macrophage as the principal antigen-presenting cell for liposome-encapsulated antigen

1992 • 29 citations

Differential effect of interleukin 1 on naive and memory CD4⁺ T cells

1992 • 25 citations

Occurrence of a silencer of the interleukin‐2 gene in naive but not in memory resting T helper lymphocytes

1993 • 23 citations

A co-stimulatory role for CD28 in the activation of CD4⁺ T lymphocytes by staphylococcal enterotoxin B

1992 • 22 citations

Increased Protein Kinase C Activity in Human Memory T Cells

1993 • 16 citations

Effector Functions of Helper T Cells

1993 • 9 citations

Adhesion Molecules in Tonsil DC-T Cell Interactions

1993 • 8 citations