Back to search

Nuclear hormone receptors in diabetic nephropathy

Data up to Jan 2025

Published2010
Citations34
References123

Total Citations Per Year

Abstract

References (123)

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Systematic review and meta-analysis

2019 • 2,911 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis

2007 • 1,928 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

2009 • 1,475 citations

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease

2006 • 1,440 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Targeting bile-acid signalling for metabolic diseases

2008 • 1,237 citations

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

2008 • 1,163 citations

Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network

2006 • 952 citations

Sorting out the roles of PPAR in energy metabolism and vascular homeostasis

2006 • 874 citations

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

2008 • 790 citations

Activated Injectable Vitamin D and Hemodialysis Survival

2005 • 780 citations

Estrogen Signaling: A Subtle Balance Between ER and ER

2003 • 778 citations

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

1998 • 776 citations

Peroxisome proliferator-activated receptors in inflammation control

2001 • 759 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Effect of lipid reduction on the progression of renal disease: A meta-analysis

2001 • 669 citations

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

2008 • 655 citations

Effect of Gender on the Progression of Nondiabetic Renal Disease

2000 • 650 citations

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis

2008 • 634 citations

Intercapillary Lesions in the Glomeruli of the Kidney.

1936 • 606 citations

Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

2005 • 591 citations

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

2008 • 529 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

2004 • 440 citations

Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor γ ligand

2005 • 415 citations

Vitamin D and Bone Health

1996 • 412 citations

Estrogen receptor β acts as a dominant regulator of estrogen signaling

2000 • 366 citations

Diet-induced Obesity in C57BL/6J Mice Causes Increased Renal Lipid Accumulation and Glomerulosclerosis via a Sterol Regulatory Element-binding Protein-1c-dependent Pathway

2005 • 365 citations

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.

1995 • 361 citations

Plasma membrane estrogen receptors

2009 • 341 citations

Lipotoxicity

2006 • 335 citations

Role of Sterol Regulatory Element-binding Protein 1 in Regulation of Renal Lipid Metabolism and Glomerulosclerosis in Diabetes Mellitus

2002 • 327 citations

Physiology and pathophysiology of canonical transient receptor potential channels

2008 • 320 citations

From Fibrosis to Sclerosis

2008 • 305 citations

Renoprotective role of the vitamin D receptor in diabetic nephropathy

2007 • 296 citations

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

2008 • 293 citations

Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease

2001 • 291 citations

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

2002 • 288 citations

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

2008 • 285 citations

Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVBdb/db Mice With Type 2 Diabetes

2005 • 281 citations

Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression

2002 • 278 citations

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

2006 • 277 citations

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

2001 • 271 citations

Regulation of Macrophage Functions by PPAR-α, PPAR-γ, and LXRs in Mice and Men

2008 • 270 citations

Acetylation Regulates Transcription Factor Activity at Multiple Levels

2000 • 268 citations

PPARα: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

2007 • 261 citations

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

2002 • 254 citations

Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor–Mediated Sequestration of NF-κB Signaling

2008 • 247 citations

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

2008 • 231 citations

Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans

1997 • 221 citations

Protection of the kidney by thiazolidinediones: An assessment from bench to bedside

2006 • 214 citations

Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy

2007 • 213 citations

PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice

2006 • 192 citations

Gender and the Progression of Renal Disease

2002 • 187 citations

Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4

1997 • 179 citations

1,25-Dihydroxyvitamin D3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells

2007 • 169 citations

Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure

2000 • 163 citations

The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria

2009 • 163 citations

Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell Inflammation and Migration

2007 • 154 citations

Antihypertensive effects of CS-045 treatment in obese Zucker rats

1993 • 153 citations

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice

2009 • 141 citations

The Renin-Angiotensin System and Diabetic Nephropathy

2007 • 135 citations

Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator–Activated Receptor α

2006 • 134 citations

Structural-functional correlations of diabetic nephropathy

1994 • 133 citations

Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury

2009 • 123 citations

Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats.

1993 • 122 citations

Immunolocalization of calcitriol receptor, 24-hydroxylase cytochrome P-450, and calbindin D28k in human kidney

1994 • 117 citations

PPAR Agonists Protect Mesangial Cells from Interleukin 1β-Induced Intracellular Lipid Accumulation by Activating the ABCA1 Cholesterol Efflux Pathway

2003 • 113 citations

Nuclear receptors: Genomic and non-genomic effects converge

2009 • 109 citations

Peroxisome Proliferator-Activated Receptor β/δ Exerts a Strong Protection from Ischemic Acute Renal Failure

2005 • 103 citations

PPAR-α and -γ agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse

2006 • 103 citations

1,25-Dihydroxyvitamin D3suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway

2009 • 102 citations

Global Transcription Profiling of Estrogen Activity: Estrogen Receptor α Regulates Gene Expression in the Kidney

2003 • 99 citations

PPARs and the kidney in metabolic syndrome

2008 • 99 citations

Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist

2009 • 91 citations

Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice

2005 • 90 citations

Selective estrogen receptor modulators suppress mesangial cell collagen synthesis

2000 • 89 citations

Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

2007 • 87 citations

Estrogen-Related Abnormalities in Glomerulosclerosis-Prone Mice

2002 • 86 citations

Estrogens and the diabetic kidney

2008 • 81 citations

Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat

2008 • 80 citations

Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy

2006 • 78 citations

17 β-estradiol and tamoxifen upregulate estrogen receptor β expression and control podocyte signaling pathways in a model of type 2 diabetes

2009 • 77 citations

Effects of Estradiol and Its Metabolites on Glomerular Endothelial Nitric Oxide Synthesis and Mesangial Cell Growth

2001 • 73 citations

Peroxisome Proliferator–Activated Receptor α/γ Dual Agonist Tesaglitazar Attenuates Diabetic Nephropathy in db/db Mice

2007 • 73 citations

HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy

2008 • 69 citations

Canonical Transient Receptor Potential 1 Channel Is Involved in Contractile Function of Glomerular Mesangial Cells

2007 • 66 citations

Discovery of Ligands for the Nuclear Peroxisome Proliferator‐activated Receptors

1996 • 64 citations

Serine/Threonine Phosphorylation of Orphan Receptor Hepatocyte Nuclear Factor 4

1997 • 63 citations

Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats

2009 • 63 citations

LOX-1 and inflammation: a new mechanism for renal injury in obesity and diabetes

2008 • 59 citations

Characterization of the human peroxisome proliferator activated receptor delta gene and its expression.

2000 • 57 citations

Liver X receptor-α mediates cholesterol efflux in glomerular mesangial cells

2004 • 56 citations

Fenofibrate Treatment of Diabetic Rats Reduces Nitrosative Stress, Renal Cyclooxygenase-2 Expression, and Enhanced Renal Prostaglandin Release

2007 • 56 citations

Dietary lipids regulate β-oxidation enzyme gene expression in the developing rat kidney

1998 • 52 citations

Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-β–regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4

2003 • 51 citations

After the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study: Implications for Fenofibrate

2008 • 50 citations

Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm.

1993 • 49 citations

Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule

2005 • 47 citations

PPARα attenuates the proinflammatory response in activated mesangial cells

2008 • 46 citations

Peroxisome Proliferator–Activated Receptor α Protects against Glomerulonephritis Induced by Long-Term Exposure to the Plasticizer Di-(2-Ethylhexyl)Phthalate

2006 • 44 citations

Effect of Bezafibrate or Pravastatin on Serum Lipid Levels and Albuminuria in NIDDM Patients

2000 • 40 citations

Emerging role of PPAR ligands in the management of diabetic nephropathy

2009 • 40 citations

Synthesis, Characterization, and Receptor Interaction Profiles of Enantiomeric Bile Acids

2007 • 40 citations

The Selective Vitamin D Receptor Activator for Albuminuria Lowering (VITAL) Study: Study Design and Baseline Characteristics

2009 • 38 citations

Activation of liver X receptor-α reduces activation of the renal and cardiac renin–angiotensin–aldosterone system

2010 • 38 citations

The role of HNF4A variants in the risk of type 2 diabetes

2005 • 33 citations

THE ROLE OF LIPID DEPOSITION IN RENAL ARTERIOLAR SCLEROSIS

1950 • 30 citations

Association of estrogen receptor with plasma-membrane caveola components: implication in control of vitamin D receptor

2007 • 27 citations

Cited By (0)

Loading...