Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell Inflammation and Migration

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Identification of a Nuclear Receptor for Bile Acids

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Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

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The Emerging Concept of Vascular Remodeling

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Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

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Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1999 • 1,065 citations

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

2006 • 881 citations

Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture

2004 • 798 citations

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

2002 • 685 citations

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

2000 • 461 citations

Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene

1998 • 408 citations

Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages

1999 • 294 citations

Expression and activation of the farnesoid X receptor in the vasculature

2004 • 222 citations

A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis

2005 • 175 citations

FXR Deficiency Causes Reduced Atherosclerosis inLdlr^−/−Mice

2006 • 160 citations

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

2005 • 160 citations

Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells.

1994 • 156 citations

The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression

2006 • 145 citations

Downregulation of Endothelin-1 by Farnesoid X Receptor in Vascular Endothelial Cells

2005 • 136 citations

Effects of FXR in foam-cell formation and atherosclerosis development

2006 • 127 citations

Expression of the αvβ6 Integrin Promotes Migration and Invasion in Squamous Carcinoma Cells

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Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

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Molecular mechanisms of iNOS induction by IL-1β and IFN-γ in rat aortic smooth muscle cells

2002 • 93 citations

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

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p38 MAPK and NF-κB mediate COX-2 expression in human airway myocytes

2003 • 89 citations

Differential Induction of Cyclooxygenase-2 in Human Arterial and Venous Smooth Muscle

1998 • 81 citations

Disruption of an SP2/KLF6 Repression Complex by SHP Is Required for Farnesoid X Receptor-induced Endothelial Cell Migration

2006 • 75 citations

Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessels of long-term cholesterol-fed rabbits

1999 • 64 citations

Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-γ Ligand Therapy

2002 • 60 citations

Role for Nuclear Factor-κB and Signal Transducer and Activator of Transcription 1/Interferon Regulatory Factor-1 in Cytokine-Induced Endothelin-1 Release in Human Vascular Smooth Muscle Cells

2003 • 58 citations

Expression of nitric oxide synthase by cytokines in vascular smooth muscle cells.

1994 • 51 citations

The Nuclear Receptors FXR and LX alpha Potential Targets for the Development of Drugs Affecting Lipid Metabolism and Neoplastic Diseases

2001 • 48 citations

Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes

2002 • 31 citations

Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells

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Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

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Location-dependent artifact for no measurement using multiwell plates

1996 • 13 citations