Liver X receptor-α mediates cholesterol efflux in glomerular mesangial cells

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2000 • 1,623 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

2001 • 1,134 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

LIPID NEPHROTOXICITY IN CHRONIC PROGRESSIVE GLOMERULAR AND TUBULO-INTERSTITIAL DISEASE

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 • 913 citations

Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

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Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

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Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats

1988 • 413 citations

Troglitazone Inhibits Formation of Early Atherosclerotic Lesions in Diabetic and Nondiabetic Low Density Lipoprotein Receptor–Deficient Mice

2001 • 396 citations

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

1996 • 378 citations

Cellular Lipid Metabolism and the Role of Lipids in Progressive Renal Disease

2004 • 269 citations

Putative Metabolic Effects of the Liver X Receptor (LXR)

2004 • 249 citations

Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans

1997 • 221 citations

Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells

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Peroxisome Proliferator-Activated Receptors, Coactivators, and Downstream Targets

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Lipids and Progressive Glomerulosclerosis

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Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats

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Peroxisome proliferator-activated receptor-γ agonist troglitazone protects against nondiabetic glomerulosclerosis in rats

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Early Mechanisms of Renal Injury in Hypercholesterolemic or Hypertriglyceridemic Rats

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Accumulation of Foam Cells in Liver X Receptor-Deficient Mice

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Analogous pathobiologic mechanisms in glomerulosclerosis and atherosclerosis.

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Decoding Transcriptional Programs Regulated by PPARs and LXRs in the Macrophage

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Peroxisome Proliferator-Activated Receptor γ: Implications for Cardiovascular Disease

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PPAR Agonists Protect Mesangial Cells from Interleukin 1β-Induced Intracellular Lipid Accumulation by Activating the ABCA1 Cholesterol Efflux Pathway

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Dysregulation of LDL receptor under the influence of inflammatory cytokines: A new pathway for foam cell formation11See Editorial by van Zonneveld and Rabelink, p. 2037

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The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

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LXRs: new therapeutic targets in atherosclerosis?

2003 • 101 citations

Cholesterol uptake in adrenal and gonadal tissues the SR BI and selective pathway connection

2003 • 99 citations

Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion

2000 • 98 citations

Peroxisome Proliferator-Activated Receptor γ Agonist Provides Superior Renal Protection versus Angiotensin-Converting Enzyme Inhibition in a Rat Model of Type 2 Diabetes with Obesity

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LXRα functions as a cAMP-responsive transcriptional regulator of gene expression

2000 • 83 citations

Peroxisome proliferator-activated receptor-γ activity is associated with renal microvasculature

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Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home

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Modulation of PPARγ activity with pharmaceutical agents: Treatment of insulin resistance and atherosclerosis

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Native LDL Upregulation of ATP-Binding Cassette Transporter-1 in Human Vascular Endothelial Cells

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Glomerular structures and lipids in progressive renal disease.

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Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression

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Inflammation modifies lipid-mediated renal injury

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Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1

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Relationship between Hyperlipidemia, Lipid Mediators, and Progressive Glomerulosclerosis in the Nephrotic Syndrome

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