Renoprotective role of the vitamin D receptor in diabetic nephropathy

Genomic sequencing.

1984 • 8,343 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome

1998 • 1,822 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,778 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,556 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,096 citations

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia

1997 • 933 citations

Survival of Patients Undergoing Hemodialysis with Paricalcitol or Calcitriol Therapy

2003 • 930 citations

Rearrangements of the Cytoskeleton and Cell Contacts Induce Process Formation during Differentiation of Conditionally Immortalized Mouse Podocyte Cell Lines

1997 • 867 citations

1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

2001 • 849 citations

End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

1999 • 796 citations

Activated Injectable Vitamin D and Hemodialysis Survival

2005 • 780 citations

Paracrine regulation of the renal microcirculation

1996 • 740 citations

Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure

2004 • 599 citations

Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems

2004 • 565 citations

Pathogenesis, prevention, and treatment of diabetic nephropathy

1998 • 560 citations

Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System

2003 • 558 citations

Mediators of Diabetic Renal Disease

2004 • 449 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin

2004 • 437 citations

Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

2005 • 424 citations

Antiproteinuric effect of oral paricalcitol in chronic kidney disease

2005 • 371 citations

Lower risk for cardiovascular mortality in oral 1 -hydroxy vitamin D3 users in a haemodialysis population

2003 • 351 citations

Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations

1993 • 307 citations

Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis

2000 • 290 citations

Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy

2000 • 285 citations

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor–Deficient Mice

2006 • 280 citations

The Paradox of the Low-Renin State in Diabetic Nephropathy

1999 • 270 citations

Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy

2000 • 266 citations

Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic Rats

2007 • 252 citations

Renal Interstitial Fluid Concentrations of Angiotensins I and II in Anesthetized Rats

2002 • 230 citations

High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells

2004 • 223 citations

1,25-Dihydroxyvitamin D₃decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat

2004 • 221 citations

The intrarenal renin–angiotensin system and diabetic nephropathy

2003 • 217 citations

Vitamin D and its analogues: Do they protect against cardiovascular disease in patients with kidney disease?

2005 • 174 citations

Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients

2000 • 172 citations

1,25-Dihydroxyvitamin D3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells

2007 • 169 citations

A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

1998 • 166 citations

Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats

2006 • 151 citations

Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism

2001 • 150 citations

Mechanism of Increased Angiotensin II Levels in Glomerular Mesangial Cells Cultured in High Glucose

2003 • 148 citations

A Vitamin D Analog Ameliorates Glomerular Injury on Rat Glomerulonephritis

2001 • 138 citations

Functional expression of the renin-angiotensin system in human podocytes

2005 • 135 citations

Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat

2000 • 133 citations

Prevention and treatment of diabetic nephropathy

2005 • 114 citations

Activation of the renin–angiotensin system within podocytes in diabetes

2007 • 109 citations

Amelioration of Diabetic Nephropathy in SPARC-Null Mice

2003 • 99 citations

The renin–angiotensin system and the long‐term complications of diabetes: pathophysiological and therapeutic considerations

2003 • 83 citations

Effect of ANG II type I receptor antagonist and ACE inhibitor on vitamin D receptor-null mice

2003 • 80 citations

Analogs of 1α,25-dihydroxyvitamin D3 as novel inhibitors of renin biosynthesis

2005 • 78 citations

Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy

2006 • 78 citations

Connective tissue growth factor: just another factor in renal fibrosis?

2000 • 68 citations

1,25-(OH2)D3 Alters the Transforming Growth Factor β Signaling Pathway in Renal Tissue

2001 • 66 citations

Update on vitamin D and its newer analogues: Actions and rationale for treatment in chronic renal failure

2002 • 63 citations

Pathogenesis of Diabetic Nephropathy

2004 • 51 citations

A Vitamin D Analog Regulates Mesangial Cell Smooth Muscle Phenotypes in a Transforming Growth Factor-β Type II Receptor-mediated Manner

1999 • 34 citations

Glomerular basement membrane thickness--a comparison of two methods of measurement in patients with unexplained haematuria

1996 • 28 citations

Deleted Work

1955 • 0 citations