Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Inflammation and metabolic disorders

2006 • 8,000 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Alternative activation of macrophages

2003 • 5,952 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

2007 • 4,269 citations

Inflammation and insulin resistance

2006 • 4,264 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

2006 • 2,496 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 • 2,035 citations

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

2007 • 1,925 citations

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

2003 • 1,893 citations

IKK-β links inflammation to obesity-induced insulin resistance

2005 • 1,710 citations

PPARs and the complex journey to obesity

2004 • 1,543 citations

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

2006 • 1,410 citations

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

2005 • 1,376 citations

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

2006 • 1,206 citations

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

2007 • 1,205 citations

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 • 1,157 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

2006 • 875 citations

Mechanisms of obesity-associated insulin resistance: many choices on the menu

2007 • 765 citations

Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology

2004 • 714 citations

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

2007 • 678 citations

Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

2001 • 591 citations

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2003 • 584 citations

Th1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells

1999 • 558 citations

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

2007 • 551 citations

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

2007 • 447 citations

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages

2002 • 433 citations

Peroxisome Proliferator-Activated Receptors: From Genes to Physiology

2001 • 425 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

Kinetics of Central Nervous System Microglial and Macrophage Engraftment: Analysis Using a Transgenic Bone Marrow Transplantation Model

1997 • 336 citations

Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

2001 • 310 citations

PPARδ is a very low-density lipoprotein sensor in macrophages

2003 • 297 citations

SHIP Represses the Generation of Alternatively Activated Macrophages

2005 • 296 citations

Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression

2004 • 233 citations

The PPARδ agonist GW0742X reduces atherosclerosis in LDLR−/− mice

2005 • 206 citations

Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance

2006 • 175 citations

Aberrant Forkhead Box O1 Function Is Associated with Impaired Hepatic Metabolism

2006 • 114 citations

Innate immunity in the liver

2003 • 109 citations

Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages

2006 • 27 citations