Human papillomavirus (HPV) 16 E6 sensitizes cells to atractyloside-induced apoptosis: Role of p53, ICE-like proteases and the mitochondrial permeability transition

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The mitochondrial permeability transition

1995 • 2,412 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

HUMAN GENITAL CANCER: SYNERGISM BETWEEN TWO VIRUS INFECTIONS OR SYNERGISM BETWEEN A VIRUS INFECTION AND INITIATING EVENTS?

1982 • 490 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1996 • 280 citations

The ADP-ATP Translocation in mitochondria, a membrane potential controlled transport

1980 • 262 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest

1994 • 185 citations

Oxidative damage to mitochondria is mediated by the Ca2+-dependent inner-membrane permeability transition

1993 • 151 citations

Functional p53 protein in human papillomavirus-positive cancer cells.

1995 • 146 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

1995 • 92 citations

Bcl‐2 protooncogene expression in cervical carcinoma cell lines containing inactive p53

1995 • 76 citations

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.

1995 • 73 citations

Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids.

1990 • 72 citations

Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1994 • 68 citations

Topography of the membrane-bound ADP/ATP carrier assessed by enzymic proteolysis

1992 • 61 citations

HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines

1996 • 55 citations

On the mechanism by which Mg2+ and adenine nucleotides restore membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphate

1983 • 38 citations

Involvement of the ADP/ATP carrier in permeabilization processes of the inner mitochondrial membrane

1993 • 27 citations

Interaction of adriamycin aglycones with isolated mitochondria

1993 • 22 citations

Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts

1994 • 19 citations

Conditional immortalization of primary cells by human papillomavirus type 18 E6 and EJ-ras defines an E6 activity in G0/G1 phase which can be substituted for mutations in p53.

1995 • 16 citations