Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

1985 • 600 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Polyadenylic Acid Sequences in the Heterogeneous Nuclear RNA and Rapidly-Labeled Polyribosomal RNA of HeLa Cells: Possible Evidence for a Precursor Relationship

1971 • 503 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells

1986 • 235 citations

Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

1987 • 230 citations

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

1991 • 216 citations

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

1991 • 182 citations

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1989 • 178 citations

Papillomavirus infection of the lower genital tract: Detection of viral DNA in gynecological swabs

1985 • 171 citations

Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells

1988 • 143 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer.

1986 • 121 citations

Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

1988 • 118 citations

Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter

1988 • 112 citations

Functional dissociation of transforming genes of human papillomavirus type 16

1988 • 91 citations

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

1992 • 72 citations

Histological types of carcinoma of the uterine cervix and the detectability of human papillomavirus DNA.

1985 • 60 citations

Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.

1990 • 53 citations

Comparative Study on E6 and E7 Genes of Some Cutaneous and Genital Papillomaviruses of Human Origin for Their Ability to Transform 3Y1 Cells

1993 • 34 citations

Progression of rat embryo fibroblast cells immortalized with transforming genes of human papillomavirus type 16

1991 • 18 citations

Stability of p53 protein in rat cells transformed by various viral transforming genes

1992 • 11 citations