mTOR: taking cues from the immune microenvironment

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

CD4 T cells: fates, functions, and faults

2008 • 1,618 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

mTOR and cancer: insights into a complex relationship

2006 • 1,299 citations

Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

2002 • 1,176 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

The Two TORCs and Akt

2007 • 782 citations

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

2008 • 741 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

2005 • 621 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Expanding mTOR signaling

2007 • 527 citations

Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance

2002 • 448 citations

Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance

2007 • 416 citations

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

2008 • 383 citations

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

2008 • 375 citations

Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

2003 • 373 citations

Activation of dendritic cells: translating innate into adaptive immunity

2003 • 360 citations

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

2006 • 342 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

2007 • 268 citations

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

2008 • 265 citations

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

2007 • 254 citations

Rapamycin-Treated, Alloantigen-Pulsed Host Dendritic Cells Induce Ag-Specific T Cell Regulation and Prolong Graft Survival

2005 • 242 citations

TOR Signaling

2003 • 222 citations

Toll-like receptors and acquired immunity

2004 • 207 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

2006 • 189 citations

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

2008 • 180 citations

How does the immune system distinguish self from nonself?

2000 • 162 citations

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

2003 • 145 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

2008 • 119 citations

The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice

2007 • 112 citations

T Cell Effector Function and Anergy Avoidance Are Quantitatively Linked to Cell Division

2000 • 101 citations

Intracellular Signaling by Akt: Bound to Be Specific

2008 • 96 citations

Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

2001 • 85 citations

Impact of Mammalian Target of Rapamycin Inhibition on Lymphoid Homing and Tolerogenic Function of Nanoparticle-Labeled Dendritic Cells following Allogeneic Hematopoietic Cell Transplantation

2008 • 80 citations

IL-1β-Driven ST2L Expression Promotes Maturation Resistance in Rapamycin-Conditioned Dendritic Cells

2008 • 77 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Clonal Anergy Is Maintained Independently of T Cell Proliferation

2002 • 49 citations

The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G1 Cell Cycle Arrest from Tolerance Induction

2004 • 47 citations

Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment

2005 • 47 citations

TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

2001 • 46 citations

Dissecting the mechanism of T-cell anergy with immunophilin ligands.

2006 • 35 citations

mTOR: dissecting regulation and mechanism of action to understand human disease

2009 • 29 citations

Can mTOR inhibitors reduce the risk of late kidney allograft failure?

2007 • 20 citations

Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A

2008 • 10 citations