mTOR: dissecting regulation and mechanism of action to understand human disease

The impact of O2 availability on human cancer

2008 • 1,279 citations

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 • 744 citations

A complex interplay between Akt, TSC2 and the two mTOR complexes

2009 • 691 citations

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

2005 • 519 citations

New roles for the LKB1→AMPK pathway

2005 • 256 citations

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

2007 • 253 citations

Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease

2007 • 218 citations

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway

2009 • 164 citations

Placental mTOR links maternal nutrient availability to fetal growth

2009 • 146 citations

The Genetics of Heteromeric Amino Acid Transporters

2005 • 140 citations

mTORC1 signalling and mRNA translation

2009 • 127 citations

Amino-acid-induced signalling via the SPS-sensing pathway in yeast

2009 • 123 citations

PI3K inhibitors for cancer treatment: where do we stand?

2009 • 108 citations

Therapeutic targeting of mTOR in tuberous sclerosis

2009 • 94 citations

A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size

2009 • 90 citations

Prolyl hydroxylases as regulators of cell metabolism

2009 • 82 citations

Rag proteins regulate amino-acid-induced mTORC1 signalling

2009 • 81 citations

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1

2009 • 68 citations

Amino acid sensing and mTOR regulation: inside or out?

2009 • 48 citations

TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress

2009 • 40 citations

Amino acid transporters: éminences grises of nutrient signalling mechanisms?

2009 • 39 citations

Translational responses to growth factors and stress

2009 • 30 citations

Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression

2009 • 27 citations