Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

2007 • 383 citations

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis

2006 • 359 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

2003 • 324 citations

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

2003 • 298 citations

Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

2007 • 253 citations

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

2005 • 248 citations

Regulatory T-cell therapy: is it ready for the clinic?

2005 • 195 citations

Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

2006 • 189 citations

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

1995 • 187 citations

The Pim kinases control rapamycin-resistant T cell survival and activation

2005 • 182 citations

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

1997 • 159 citations

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

2001 • 127 citations

B and T Lymphocyte Attenuator-Mediated Signal Transduction Provides a Potent Inhibitory Signal to Primary Human CD4 T Cells That Can Be Initiated by Multiple Phosphotyrosine Motifs

2006 • 77 citations

The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines: Figure 1.

2003 • 75 citations

Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers

2006 • 68 citations

Expression of human pim family genes is selectively up‐regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation

2005 • 47 citations