The Two TORCs and Akt

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

2006 • 1,365 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

2004 • 1,307 citations

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

2006 • 1,293 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

Phosphorylation and Functional Inactivation of TSC2 by Erk

2005 • 1,229 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

2002 • 1,147 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

2007 • 1,132 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Influence of TOR kinase on lifespan in C. elegans

2003 • 1,017 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Rheb Binds and Regulates the mTOR Kinase

2005 • 957 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 • 908 citations

PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

2005 • 872 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

2003 • 809 citations

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

2003 • 808 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

PDK1, the master regulator of AGC kinase signal transduction

2004 • 785 citations

The Akt-mTOR tango and its relevance to cancer

2005 • 778 citations

Autophagy in metazoans: cell survival in the land of plenty

2005 • 752 citations

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 • 744 citations

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

2004 • 737 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

2003 • 708 citations

The TOR pathway interacts with the insulin signaling pathway to regulateC. eleganslarval development, metabolism and life span

2004 • 682 citations

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

2006 • 680 citations

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

2006 • 668 citations

(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms

2006 • 666 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

2004 • 606 citations

Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth

2006 • 597 citations

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

2004 • 573 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

2005 • 540 citations

Emerging roles of pseudokinases

2006 • 528 citations

Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity

2005 • 526 citations

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

2005 • 519 citations

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis

2002 • 515 citations

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt

2006 • 499 citations

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

2005 • 498 citations

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

2006 • 497 citations

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

2002 • 492 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

2004 • 464 citations

mTOR and cancer therapy

2006 • 460 citations

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

2005 • 433 citations

Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

2005 • 432 citations

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

2002 • 416 citations

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

2003 • 412 citations

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

2005 • 399 citations

Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

2006 • 384 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

2006 • 373 citations

Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

2003 • 370 citations

Restraining PI3K: mTOR signalling goes back to the membrane

2004 • 360 citations

The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses

2005 • 357 citations

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

2003 • 356 citations

Recent advances in the protein kinase B signaling pathway

2005 • 348 citations

PTEN: from pathology to biology

2003 • 345 citations

Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency

2005 • 343 citations

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

2006 • 342 citations

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

2000 • 338 citations

eIF4E expression in tumors: its possible role in progression of malignancies

1999 • 327 citations

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

2007 • 297 citations

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

2004 • 294 citations

S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt

2006 • 284 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Activation of Akt/Protein Kinase B Overcomes a G₂/M Cell Cycle Checkpoint Induced by DNA Damage

2002 • 272 citations

TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation

2002 • 271 citations

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

2006 • 266 citations

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

2001 • 254 citations

The deficiency ofAkt1is sufficient to suppress tumor development inPten^+/−mice

2006 • 241 citations

Molecular Organization of Target of Rapamycin Complex 2

2005 • 236 citations

Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex

2005 • 235 citations

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner

2006 • 232 citations

TOR Signaling

2003 • 222 citations

Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization

2005 • 214 citations

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

2005 • 204 citations

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain

1999 • 198 citations

TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium

2005 • 196 citations

Roles of Erbb family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

2002 • 191 citations

Exogenous Amino Acids Regulate Trophectoderm Differentiation in the Mouse Blastocyst through an mTOR-Dependent Pathway

2001 • 186 citations

Localization of Rheb to the endomembrane is critical for its signaling function

2006 • 185 citations

Role of S6 phosphorylation and S6 kinase in cell growth

2000 • 182 citations

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

2006 • 179 citations

Autophagy in Yeast: ATOR-Mediated Response to Nutrient Starvation

2004 • 178 citations

Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

2000 • 178 citations

Lost in translation

2004 • 173 citations

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.

1992 • 172 citations

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

2006 • 172 citations

Deletion of the Intestinal Peptide Transporter Affects Insulin and TOR Signaling in Caenorhabditis elegans

2004 • 167 citations

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

2001 • 167 citations

The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3

2003 • 165 citations

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

2003 • 156 citations

Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

2002 • 154 citations

The Solution Structure of the FATC Domain of the Protein Kinase Target of Rapamycin Suggests a Role for Redox-dependent Structural and Cellular Stability

2005 • 126 citations

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase

2006 • 121 citations

Drosophila Melted Modulates FOXO and TOR Activity

2005 • 111 citations

Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe

2004 • 109 citations

Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1

2006 • 109 citations

Loss of Rhb1, a Rheb-Related GTPase in Fission Yeast, Causes Growth Arrest With a Terminal Phenotype Similar to That Caused by Nitrogen Starvation

2000 • 105 citations

Role of the Tsc1-Tsc2 Complex in Signaling and Transport Across the Cell Membrane in the Fission Yeast Schizosaccharomyces pombe

2002 • 104 citations

Tsc2 is not a critical target of Akt during normal Drosophila development

2004 • 102 citations

Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway

2005 • 100 citations

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

2002 • 99 citations

Aberrant β-Catenin Signaling in Tuberous Sclerosis

2005 • 99 citations

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

2005 • 92 citations

Drosophila Target of Rapamycin Kinase Functions as a Multimer

2005 • 84 citations

Cell Cycle-regulated Phosphorylation of Hamartin, the Product of the Tuberous Sclerosis Complex 1 Gene, by Cyclin-dependent Kinase 1/Cyclin B

2003 • 77 citations

Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro

2000 • 76 citations

TOR Action in Mammalian Cells and in Caenorhabditis elegans

2004 • 65 citations

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway

1999 • 65 citations

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

2001 • 62 citations

Interplay Between Growth Factor and Nutrient Signaling: Lessons from Drosophila TOR

2004 • 54 citations

Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation

2005 • 43 citations

Phosphorylation and binding partner analysis of the TSC1–TSC2 complex

2005 • 38 citations

Systems Biology of AGC Kinases in Fungi

2006 • 36 citations

The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins

2004 • 32 citations

Genetic Analysis of TOR Signaling in Drosophila

2004 • 28 citations