A causal link between lymphopenia and autoimmunity

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Inflammatory Bowel Disease

2002 • 3,038 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

Experimental Parvoviral Infection in Humans

1985 • 718 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

2002 • 703 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis

2001 • 519 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

1999 • 456 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2003 • 448 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

RESULTS FROM A HUMAN RENAL ALLOGRAFT TOLERANCE TRIAL EVALUATING THE HUMANIZED CD52-SPECIFIC MONOCLONAL ANTIBODY ALEMTUZUMAB (CAMPATH-1H)

2003 • 432 citations

A potential role for interleukin-7 in T-cell homeostasis

2001 • 415 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.

2003 • 401 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

2004 • 387 citations

Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study

2003 • 379 citations

HIV and autoimmunity

2002 • 369 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 312 citations

DIETARY FACTORS ASSOCIATED WITH DEATH-RATES FROM CERTAIN NEOPLASMS IN MAN

1966 • 311 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

CD25⁺CD4⁺regulatory T cells suppress CD4⁺T cell‐mediated pulmonary hyperinflammation driven byPneumocystis cariniiin immunodeficient mice

2002 • 276 citations

Perturbation of the T cell repertoire in rheumatoid arthritis

1998 • 273 citations

A new look at viruses in type 1 diabetes

2002 • 264 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

2002 • 262 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 262 citations

Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans

2000 • 253 citations

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

2001 • 249 citations

CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice

2002 • 245 citations

HIGH FREQUENCY OF DIABETES MELLITUS IN YOUNG ADULTS WITH CONGENITAL RUBELLA

1971 • 243 citations

CONVERSION OF ATRIAL FIBRILLATION TO SINUS RHYTHM BY DIRECT-CURRENT SHOCK

1963 • 237 citations

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

2004 • 235 citations

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

1992 • 230 citations

Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients

2004 • 226 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

Rheumatologic Manifestations of Infection with Human Immunodeficiency Virus (HIV)

1989 • 189 citations

Spontaneous thyroiditis in thymectomized and irradiated Wistar rats.

1973 • 179 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment

2000 • 153 citations

Multiple Sclerosis and Age at Infection with Common Viruses

2001 • 145 citations

Lymphopenia In Systemic Lupus Erythematosus

1978 • 145 citations

Disrupting T-cell homeostasis: how HIV-1 infection causes disease.

2003 • 136 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

High-Dose Methylprednisolone Therapy in Multiple Sclerosis Induces Apoptosis in Peripheral Blood Leukocytes

2001 • 132 citations

A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation

2001 • 130 citations

Prognostic parameters for flare in systemic lupus erythematosus

2000 • 125 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

Self-tolerance: context dependent tuning of T cell antigen recognition

2000 • 121 citations

IL-12 Enhances CD8 T Cell Homeostatic Expansion

2001 • 121 citations

ABNORMALITIES OF IN VITRO LYMPHOCYTE RESPONSES DURING RUBELLA VIRUS INFECTIONS

1968 • 120 citations

T cell homeostasis and systemic autoimmunity

2001 • 118 citations

T cell homeostasis and systemic autoimmunity

2001 • 104 citations

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

2002 • 102 citations

Influenza A (H5N1) in Hong Kong: an overview

2002 • 99 citations

A Ligand for the Chemokine Receptor CCR7 Can Influence the Homeostatic Proliferation of CD4 T Cells and Progression of Autoimmunity

2001 • 96 citations

Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire

2000 • 87 citations

Thymic Aplasia With Lymphopenia, Plasma Cells, and Normal Immunoglobulins

1967 • 82 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

A New Look at Viruses in Type 1 Diabetes

2004 • 74 citations

Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8 ⁺ T cells expressing the same or different T cell receptors

2004 • 69 citations

The Role of B7 Costimulation in CD4/CD8 T Cell Homeostasis

2000 • 68 citations

Peripheral Blood Lymphocyte Subset Counts in Patients with Dermatomyositis

2003 • 67 citations

Cellular Tolerance as a Dynamic State of the Adaptable Lymphocyte

1993 • 66 citations

West Nile virus in the United States: an update on an emerging infectious disease.

2003 • 62 citations

Measles Virus 1998–2002: Progress and Controversy

2003 • 59 citations

Systemic Activation and Antigen-Driven Oligoclonal Expansion of T Cells in a Mouse Model of Colitis

2000 • 58 citations

A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells

2004 • 57 citations

Virus and Autoimmunity: Induction of Autoimmune Disease in Mice by Mouse T Lymphotropic Virus (MTLV) Destroying CD4+ T Cells

1999 • 52 citations

Expression of CD25 defines peripheral blood mononuclear cells with productive versus latent HIV infection.

1995 • 51 citations

CD4+ T-lymphocytopenia without HIV infection: increased prevalence among patients with primary Sjögren's syndrome.

1995 • 45 citations

T-LYMPHOCYTE IMMUNOPHENOTYPING IN POLYMYOSITIS AND DERMATOMYOSITIS

1996 • 45 citations

Parvovirus B19 in the acute arthropathies and juvenile rheumatoid arthritis

2002 • 42 citations

In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy

2004 • 36 citations

Homeostasis of intestinal immune regulation

2002 • 34 citations

Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes.

1998 • 34 citations

Infections and risk of type I diabetes in childhood: A population-based case–control study

2002 • 33 citations

Prognostic Significance of Severe Preoperative Lymphopenia in Patients with Crohnʼs Disease

1986 • 33 citations

HIV infection

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Naïve to memory T-cell differentiation during homeostasis-driven proliferation

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Hyposplenism in gastrointestinal disease.

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Rheumatic aspects of acquired immunodeficiency syndrome

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T Helper Cell Defect Related to Severity in Measles

1987 • 23 citations

Differential Effects of X‐Irradiation and Cyclosporin‐AAdministration on the Thymus with Respect to theGeneration of Cyclosporin‐A‐Induced Autoimmunity

1994 • 22 citations

Interleukin‐7 levels may predict virological response in advanced HIV‐1‐infected patients receiving lopinavir/ritonavir‐based therapy

2003 • 20 citations

Thymic aplasia with lymphopenia, plasma cells, and normal immunoglobulins. Relation to measles virus infection

1967 • 18 citations

SUBNORMAL LYMPHOCYTE-COUNTS IN ADULT CŒLIAC DISEASE

1975 • 13 citations

Lymphopenia in Sjögren's syndrome with rheumatoid arthritis: relationship to lymphocytotoxic antibodies, cryoglobulinemia, and impaired mitogen responsiveness.

1976 • 9 citations

Pathogenesis of Cyclosporin A-Induced Autoimmunity: Absence of T-cell Reactivity Towards Syngeneic Antigen Presenting Cells

1998 • 9 citations