Perturbation of the T cell repertoire in rheumatoid arthritis

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

Mice lacking MHC class II molecules

1991 • 869 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Positive selection of lymphocytes

1994 • 563 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

1997 • 513 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

Selective Events in T Cell Development

1994 • 486 citations

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

1996 • 479 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

1975 • 387 citations

Expansion of unusual CD4+ T cells in severe rheumatoid arthritis

1997 • 286 citations

Treatment of rheumatoid arthritis with an anti‐CD4 monoclonal antibody

1991 • 279 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

T-cell regeneration: all repertoires are not created equal

1997 • 246 citations

Lymphocyte lifespans: homeostasis, selection and competition

1993 • 226 citations

The Molecular Basis of Susceptibility to Rheumatoid Arthritis

1994 • 218 citations

Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis.

1995 • 213 citations

Human cartilage glycoprotein‐39 as a candidate autoantigen in rheumatoid arthritis

1997 • 213 citations

CD4+ T-cell memory, CD45R subsets and the persistence of antigen—a unifying concept

1998 • 212 citations

Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium.

1983 • 195 citations

Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

1995 • 180 citations

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

1994 • 159 citations

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings

1996 • 136 citations

Lymphocyte homeostasis

1997 • 133 citations

T Cell Repertoires and Competitive Exclusion

1994 • 124 citations

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.

1993 • 119 citations

Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

1995 • 107 citations

A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis

1996 • 103 citations

Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4⁺CD28⁻ T cells

1997 • 100 citations

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

1995 • 97 citations

Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients.

1996 • 95 citations

Treatment of active refractory rheumatoid arthritis with humanized monoclonal antibody campath‐1h administered by daily subcutaneous injection

1995 • 67 citations

Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis

1995 • 66 citations

T CELLS IN RHEUMATOID ARTHRITIS

1995 • 32 citations

Recent clinical trials in the rheumatic diseases

1997 • 9 citations