Cellular Tolerance as a Dynamic State of the Adaptable Lymphocyte

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance

1993 • 795 citations

Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

1984 • 767 citations

Genes and Antibodies

1959 • 675 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Autoimmunity, microbial immunity and the immunological homunculus

1991 • 525 citations

Induction and Intuition in Scientific Thought

2013 • 482 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.

1977 • 392 citations

The cognitive paradigm and the immunological homunculus

1992 • 375 citations

The role of T-cell subsets and cytokines in the regulation of infection

1991 • 352 citations

Theoretical Immunology

1980 • 345 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

Developmental Aspects of Immunity

1967 • 301 citations

The mosaic of autoimmunity

1989 • 292 citations

Differentiation requires continuous regulation.

1991 • 276 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Is T-cell memory maintained by crossreactive stimulation?

1990 • 253 citations

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

1992 • 230 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

The cognitive principle challenges clonal selection

1992 • 212 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Function and Specificity of T Cell Subsets in the Mouse

1987 • 208 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Infection breaks T-cell tolerance

1992 • 174 citations

The extrathymic T-cell development pathway

1992 • 169 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance

1990 • 148 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Limit of T Cell Tolerance to Self Proteins by Peptide Presentation

1990 • 138 citations

Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

1992 • 109 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

1991 • 97 citations

Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation

1989 • 94 citations

Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway

1992 • 70 citations

SEQUENTIAL ANALYSIS OF IL-2 GENE TRANSCRIPTION IN RENAL TRANSPLANTS

1992 • 69 citations

Self Tolerance in the B‐Cell Repertoire

1991 • 69 citations

Antigen‐presenting Cells for CD8+ T Cells

1990 • 60 citations

The Absence of Antibody-Producing Cells during Unresponsiveness to BSA in the Mouse

1963 • 57 citations

Tumor escape from immune elimination

1980 • 53 citations

Recognition of self, balance of growth and competition: Horizontal networks regulate immune responsiveness

1982 • 47 citations

FACILITATION OF SPECIFIC TOLERANCE INDUCTION IN ADULT MICE BY RS-61443

1992 • 39 citations

Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses.

1986 • 39 citations

Recognition of Self and Regulation of Specificity at the Level of Cell Populations

1984 • 39 citations

Peripheral Tolerance in Transgenic Mice: Tolerance to Class II MHC and non‐MHC Transgene Antigens

1991 • 38 citations

Proliferative T cell anergy to MIs-1^a does not correlate with in vivo tolerance

1991 • 37 citations

From HIV Infection to AIDS: Are the Manifestations of Effective Immune Resistance Misinterpreted?

1993 • 37 citations

Natural killer cells and their relationship to T-cells: hypothesis on the role of T-cell receptor gene rearrangement on the course of adaptive differentiation.

1986 • 36 citations

Memory and anergy: challenges to traditional models of T lymphocyte differentiation

1992 • 31 citations

A theoretical analysis of the phenotypic expression of immune response genes

1980 • 29 citations

The Concept of Idiotypic Network: Deficient or Premature?

1989 • 25 citations

The dynamics of antibody secreting cell production: Regulation of growth and oscillations in the response to T-independent antigens

1980 • 23 citations

Some reasons why deletion and anergy do not satisfactorily account for natural tolerance

1992 • 23 citations

Contextual Discrimination of Antigens by the Immune System: Towards a Unifying Hypothesis

1992 • 23 citations

Neural Modulation of Immunity: Conditioning Phenomena and the Adaptability of Lymphoid Cells

1992 • 23 citations

‘Immune surveillance’ without immunogenicity

1986 • 22 citations

The stem cell concept revisited: Self-renewal capacity is a dynamic property of hemopoietic cells

1986 • 21 citations

Suppression of the Response to Murine Alloantigens: Four-Cell-Type Clusters, Function-Flipping and Idiosyncratic Responses

1989 • 9 citations

Mutations in the α1 domain of a class I gene define residues important for specific allorecognition

1990 • 9 citations

Clonal deletion, anergy and immunosuppressionare connected in series to guarantee self-tolerance

1992 • 9 citations

Balance of Growth Models of Cell Populations: The Significance of Simple Mathematical Considerations

1985 • 7 citations

Peripheral tolerance

1992 • 6 citations

Deletion versus anergy : the superantigen paradigm

1992 • 3 citations

T cells causing immunological disease: immunopathology or autoimmunity?

1992 • 3 citations

What is the mechanism of induction of intrathymic tolerance?

1992 • 1 citations