T cell homeostasis and systemic autoimmunity

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Regulatory T Cells

2000 • 1,827 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Replicative Senescence: An Old Lives' Tale?

1996 • 429 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment

2001 • 155 citations

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment

2000 • 153 citations

Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

1999 • 146 citations

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

2001 • 139 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

Lymphocyte homeostasis

1997 • 133 citations

IL-12 Enhances CD8 T Cell Homeostatic Expansion

2001 • 121 citations

Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 ^lck

2000 • 120 citations

Effects of mercury on the immune system.

1997 • 119 citations

Cyclosporin A-induced autoimmune disease in mice.

1993 • 115 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells.

1994 • 101 citations

Virus and Autoimmunity: Induction of Autoimmune Disease in Mice by Mouse T Lymphotropic Virus (MTLV) Destroying CD4+ T Cells

1999 • 52 citations

Abnormalities in the Export and Fate of Recent Thymic Emigrants in Diabetes-Prone BB/W Rats¹

1996 • 52 citations

G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4⁺ cells of older lupus mice

1997 • 44 citations

Cyclosporine, Tolerance, and Autoimmunity

1993 • 35 citations

Differential Effects of X‐Irradiation and Cyclosporin‐AAdministration on the Thymus with Respect to theGeneration of Cyclosporin‐A‐Induced Autoimmunity

1994 • 22 citations

Thymic Microenvironmental Abnormalities in MRL/MP-lpr/lpr, BXSB/MpJYaaand C3H HeJ-gld/gldMice

1995 • 21 citations

Autoimmunity and AIDS. A commentary.

1997 • 2 citations