Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

1998 • 9,382 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

1997 • 2,670 citations

Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy

1997 • 1,912 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Positive Effects of Combined Antiretroviral Therapy on CD4 ⁺ T Cell Homeostasis and Function in Advanced HIV Disease

1997 • 1,812 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

1998 • 722 citations

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

1999 • 598 citations

Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution

2000 • 597 citations

A Prospective Study of Human Immunodeficiency Virus Type 1 Infection and the Development of AIDS in Subjects with Hemophilia

1989 • 536 citations

Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis

2000 • 442 citations

The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

1985 • 434 citations

Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315

1998 • 431 citations

Clinical Outcome of Patients with HIV-1 Infection according to Immunologic and Virologic Response after 6 Months of Highly Active Antiretroviral Therapy

2000 • 421 citations

Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues

1999 • 339 citations

Combination Antiretroviral Therapy and Recent Declines in AIDS Incidence and Mortality

1999 • 283 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers

1992 • 275 citations

High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

1998 • 256 citations

Direct Evidence for Thymic Function in Adult Humans

1999 • 236 citations

Factors influencing T-cell turnover in HIV-1–seropositive patients

2000 • 236 citations

Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease

1998 • 231 citations

Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

1998 • 224 citations

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro , in animals, and in humans

1998 • 199 citations

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection

1999 • 198 citations

Thymic Function Can Be Accurately Monitored by the Level of Recent T Cell Emigrants in the Circulation

1998 • 193 citations

Immune Reconstitution in the First Year of Potent Antiretroviral Therapy and Its Relationship to Virologic Response

2000 • 180 citations

Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population

1996 • 178 citations

T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool

1999 • 172 citations

Thymic Size and Lymphocyte Restoration in Patients with Human Immunodeficiency Virus Infection after 48 Weeks of Zidovudine, Lamivudine, and Ritonavir Therapy

2000 • 172 citations

In vivo analysis of Fas/FasL interactions in HIV-infected patients.

1998 • 153 citations

Changing Spectrum of Mortality Due to Human Immunodeficiency Virus: Analysis of 260 Deaths during 1995-1999

2001 • 140 citations

Lifespans of naive, memory and effector lymphocytes

1993 • 133 citations

Restoration of the immune system with anti-retroviral therapy

1999 • 130 citations

Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults

1998 • 125 citations

Determinants of paradoxical CD4 cell reconstitution after protease inhibitor-containing antiretroviral regimen

1999 • 124 citations

Immune Reconstitution after 2 Years of Successful Potent Antiretroviral Therapy in Previously Untreated Human Immunodeficiency Virus Type 1–Infected Adults

1999 • 114 citations

Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1–Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration, and Virologic End Points

1999 • 107 citations

Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume

2000 • 97 citations

Alternative pathways for the selection of antigen-specific peripheral T cells

1996 • 91 citations

Postthymic T‐Cell Development

1986 • 81 citations

Early recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy

1998 • 70 citations

The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.

1997 • 65 citations

CD4+ and CD8+ T lymphocyte regeneration after anti-retroviral therapy in HIV-1-infected children and adult patients

2000 • 64 citations

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection

1999 • 54 citations