Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

Lymphocyte life-span and memory

1994 • 405 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool

1998 • 294 citations

Genetic susceptibility to post-thymectomy autoimmune diseases in mice

1981 • 265 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

Organ‐specific Autoimmunity Induced by Lymphopenia

1996 • 194 citations

Molecular detection and in vivo analysis of the specific T cell response to a protein antigen

1992 • 176 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.

1993 • 168 citations

Cd4+ T Cell Division in Irradiated Mice Requires Peptides Distinct from Those Responsible for Thymic Selection

1999 • 157 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

Innate immunity: Lipoproteins take their Toll on the host

1999 • 141 citations

Peripheral T cell survival

1999 • 116 citations

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

1995 • 87 citations

TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host

1998 • 56 citations

T-cell development: A role for self-peptides in positive selection

1999 • 26 citations

Junctional diversity in the absence of N regions. Neonatal T cell receptor beta chain junctional sequences are more heterogeneous than neonatal T cell receptor gamma delta or IgH junctions.

1993 • 13 citations